Tet-on systems for doxycycline-inducible gene expression
AT Das, L Tenenbaum, B Berkhout - Current gene therapy, 2016 - ingentaconnect.com
The tetracycline-controlled Tet-Off and Tet-On gene expression systems are used to regulate
the activity of genes in eukaryotic cells in diverse settings, varying from basic biological …
the activity of genes in eukaryotic cells in diverse settings, varying from basic biological …
Why primate models matter
Research involving nonhuman primates (NHPs) has played a vital role in many of the
medical and scientific advances of the past century. NHPs are used because of their …
medical and scientific advances of the past century. NHPs are used because of their …
Challenges in the development of an HIV-1 vaccine
DH Barouch - Nature, 2008 - nature.com
The development of a safe and effective human immunodeficiency virus (HIV)-1 vaccine is a
critically important global health priority. Despite recent advances in our understanding of …
critically important global health priority. Despite recent advances in our understanding of …
[HTML][HTML] A brief history of the global effort to develop a preventive HIV vaccine
J Esparza - Vaccine, 2013 - Elsevier
Soon after HIV was discovered as the cause of AIDS in 1983–1984, there was an
expectation that a preventive vaccine would be rapidly developed. In trying to achieve that …
expectation that a preventive vaccine would be rapidly developed. In trying to achieve that …
Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1—a report from the Sydney Blood Bank Cohort
Background and Methods The Sydney Blood Bank Cohort consists of a blood donor and
eight transfusion recipients who were infected before 1985 with a strain of human …
eight transfusion recipients who were infected before 1985 with a strain of human …
[图书][B] Handbook of laboratory animal science: Animal Models, Volume III
J Hau, SJ Schapiro, GL Van Hoosier Jr - 2004 - taylorfrancis.com
Building upon the success of the Handbook of Laboratory Animal Science and completing
Volumes I and II of the Second Edition, Handbook of Laboratory Animal Science, Second …
Volumes I and II of the Second Edition, Handbook of Laboratory Animal Science, Second …
Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression
CD8+ T cells are a key focus of vaccine development efforts for HIV. However, there is no
clear consensus as to which of the nine HIV proteins should be used for vaccination. The …
clear consensus as to which of the nine HIV proteins should be used for vaccination. The …
[HTML][HTML] Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein
TM Ross, AE Oran, BR Cullen - Current Biology, 1999 - cell.com
Background: The human immunodeficiency virus type 1 (HIV-1) Nef protein is required for
efficient virus replication in vivo and displays a number of distinct and apparently unrelated …
efficient virus replication in vivo and displays a number of distinct and apparently unrelated …
HIV vaccines
AJ McMichael - Annu. Rev. Immunol., 2006 - annualreviews.org
A prophylactic vaccine for HIV-1 is badly needed. Despite 20 years of effort, it is still a long
way off. However, considerable progress has been made in understanding the problem. The …
way off. However, considerable progress has been made in understanding the problem. The …
ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against SIVmac251 Challenge
MD Alpert, JD Harvey, WA Lauer, RK Reeves… - 2012 - journals.plos.org
Live-attenuated strains of simian immunodeficiency virus (SIV) routinely confer apparent
sterilizing immunity against pathogenic SIV challenge in rhesus macaques. Understanding …
sterilizing immunity against pathogenic SIV challenge in rhesus macaques. Understanding …