Cell-type-specific expression of molecular tools and sensors is critical to construct circuit
diagrams and to investigate the activity and function of neurons within the nervous system …

The discovery of the role of α-synuclein in the pathogenesis of Parkinson's disease (PD) has
opened new possibilities for the development of more authentic models of Parkinson's …

The resolution and dimensionality with which biologists can characterize cell types have
expanded dramatically in recent years, and intersectional consideration of such features (eg …

More than one hundred naturally occurring variants of adeno-associated virus (AAV) have
been identified, and this library has been further expanded by an array of techniques for …

Adeno-associated virus (AAV) vectors often undergo long-distance axonal transport after
brain injection. This leads to transduction of brain regions distal to the injection site, although …

Background Alpha-synuclein is a key protein implicated in the pathogenesis of Parkinson's
disease (PD). It is the main component of the Lewy bodies, a cardinal neuropathological …

The functional architecture of adult cerebral cortex retains a capacity for experience-
dependent change. This is seen following focal binocular lesions, which induce rapid …

We compared adeno-associated virus (AAV) serotypes for expression levels of green
fluorescent protein (GFP) in the adult rat hippocampus by biophotonic imaging. Preparations …

Persistent transcriptional events in ventral tegmental area (VTA) and other reward relevant
brain regions contribute to enduring behavioral adaptations that characterize substance use …

Adeno-associated viral (AAV) vectors have become the primary delivery agent for somatic
gene transfer into the central nervous system (CNS). To date, AAV-mediated gene delivery …