Abstract Background Transcription factor 7-like 2 (TCF7L2) has been shown to be
associated with type 2 diabetes mellitus (T2MD) in multiple ethnic groups in the past two …

Cells offer different types of cytoskeletal anchorages: transitory structures such as focal
contacts and perennial ones such as the sarcomeric cytoskeleton of muscle cells. The …

Abstract Background Deregulation of Wnt/β-catenin signaling is a hallmark of the majority of
sporadic forms of colorectal cancer and results in increased stability of the protein β-catenin …

Myocyte death occurs in many inherited and acquired cardiomyopathies, including
arrhythmogenic cardiomyopathy (ACM), a genetic heart disease plagued by the prevalence …

Recently, the transcription factor 7-like 2 (TCF7L2) gene has been associated with type 2
diabetes in subjects of European origin in the DeCode study. We genotyped the two most …

The actin cross-linking protein filamin A (FLNa) functions as a scaffolding protein and
couples cell cytoskeleton to extracellular matrix and integrin receptor signaling. In this study …

Colorectal cancer (CRC) is one of the most common and deadly malignancies in the world.
Most CRCs are initiated by aberrant activation of the Wnt/ß-catenin signaling pathway …

Summary eIF4E, the mRNA 5′ cap-binding translation initiation factor, is overexpressed in
numerous cancers and is implicated in mechanisms underlying oncogenesis and …

The initial report by Grant et al.[1] that variants in the TCF7L2 gene are strongly associated
with risk of developing type 2 diabetes has now been robustly reproduced in many other …

Loss-of-function mutations of retinoblastoma family (Rb) proteins drive tumorigenesis by
overcoming barriers to cellular proliferation. Consequently, factors modulating Rb function …