Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

Myofibroblasts accumulate in the spaces between organ structures and produce
extracellular matrix (ECM) proteins, including collagen I. They are the primary “effector” cells …

Idiopathic pulmonary fibrosis (IPF) is characterized by devastating and progressive lung
parenchymal fibrosis, resulting in poor patient prognosis. An aberrant recapitulation of …

Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of
extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary …

Tissue injury evokes highly conserved, tightly regulated inflammatory responses and less
well-understood host repair responses. Both inflammation and repair involve the …

Fibrosis is the production of excessive amounts of connective tissue, ie, scar formation, in
the course of reactive and reparative processes. Fibrosis develops as a consequence of …

Background Accumulation of profibrotic myofibroblasts in fibroblastic foci (FF) is a crucial
process for development of fibrosis during idiopathic pulmonary fibrosis (IPF) pathogenesis …

Idiopathic pulmonary fibrosis (IPF) is characterized by the progressive and ultimately fatal
accumulation of fibroblasts and extracellular matrix in the lung that distorts its architecture …

Transforming growth factor beta (TGF-β) is a ubiquitous and essential regulator of cellular
and physiologic processes including proliferation, differentiation, migration, cell survival …

The authors have previously shown that acute lung injury (ALI) produces a wide spectrum of
pathological processes in patients who die of severe acute respiratory syndrome (SARS) …