[HTML][HTML] A physical wiring diagram for the human immune system

J Shilts, Y Severin, F Galaway, N Müller-Sienerth… - Nature, 2022 - nature.com
The human immune system is composed of a distributed network of cells circulating
throughout the body, which must dynamically form physical associations and communicate …

[HTML][HTML] No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor

J Shilts, TWM Crozier, EJD Greenwood, PJ Lehner… - Scientific reports, 2021 - nature.com
The spike protein of SARS-CoV-2 is known to enable viral invasion into human cells through
direct binding to host receptors including ACE2. An alternate entry receptor for the virus was …

Mimicry of short linear motifs by bacterial pathogens: a drugging opportunity

H Sámano-Sánchez, TJ Gibson - Trends in biochemical sciences, 2020 - cell.com
Bacterial pathogens have developed complex strategies to successfully survive and
proliferate within their hosts. Throughout the infection cycle, direct interaction with host cells …

[HTML][HTML] Getting in: The structural biology of malaria invasion

H Kumar, NH Tolia - PLoS pathogens, 2019 - journals.plos.org
Malaria affects one third of the world's population and kills hundreds of thousands across the
globe annually. Among the species that cause malaria in humans, Plasmodium falciparum …

Plasmodium sporozoites on the move: Switching from cell traversal to productive invasion of hepatocytes

M Loubens, L Vincensini, P Fernandes… - Molecular …, 2021 - Wiley Online Library
Parasites of the genus Plasmodium, the etiological agent of malaria, are transmitted through
the bite of anopheline mosquitoes, which deposit sporozoites into the host skin. Sporozoites …

[HTML][HTML] Prospects for malaria vaccines: Pre-erythrocytic stages, blood stages, and transmission-blocking stages

J Zheng, H Pan, Y Gu, X Zuo, N Ran, Y Yuan… - BioMed research …, 2019 - hindawi.com
Malaria is a disease of public health importance in many parts of the world. Currently, there
is no effective way to eradicate malaria, so developing safe, efficient, and cost-effective …

Important extracellular interactions between Plasmodium sporozoites and host cells required for infection

K Dundas, MJ Shears, P Sinnis, GJ Wright - Trends in parasitology, 2019 - cell.com
Malaria is an infectious disease, caused by Plasmodium parasites, that remains a major
global health problem. Infection begins when salivary gland sporozoites are transmitted …

Complement receptor 1 is the human erythrocyte receptor for Plasmodium vivax erythrocyte binding protein

SK Lee, C Crosnier… - Proceedings of the …, 2024 - National Acad Sciences
The discovery that Africans were resistant to infection by Plasmodium vivax (P. vivax) led to
the conclusion that P. vivax invasion relied on the P. vivax Duffy Binding Protein (PvDBP) …

Cell invasion by intracellular parasites–the many roads to infection

MF Horta, LO Andrade… - Journal of cell …, 2020 - journals.biologists.com
Intracellular parasites from the genera Toxoplasma, Plasmodium, Trypanosoma,
Leishmania and from the phylum Microsporidia are, respectively, the causative agents of …

[HTML][HTML] Management of cell death in parasitic infections

L Bosurgi, CV Rothlin - Seminars in Immunopathology, 2021 - Springer
For a long time, host cell death during parasitic infection has been considered a reflection of
tissue damage, and often associated with disease pathogenesis. However, during their …