Delayed cerebral ischemia is a major predictor of poor outcomes in patients who suffer
subarachnoid hemorrhage. Treatment options are limited and often ineffective despite many …

Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Chronic migraine has a great detrimental influence on a patient's life, with a severe impact
on socioeconomic functioning and quality of life. Chronic migraine affects 1–2% of the …

Scientific evidence supports the notion that migraine pathophysiology involves inherited
alteration of brain excitability, intracranial arterial dilatation, recurrent activation, and …

Migraine and stroke are two common and heterogeneous neurovascular disorders
responsible for a significant burden for those affected and a great economic cost for the …

Migraine is a collection of perplexing neurological conditions in which the brain and its
associated tissues have been implicated as major players during an attack. Once …

Cortical spreading depression (CSD), a slowly propagated wave of depolarization followed
by suppression of brain activity, is a remarkably complex event that involves dramatic …

Punctuated episodes of spreading depolarizations erupt in the brain, encumbering tissue
structure and function, and raising fascinating unanswered questions concerning their …

In the mid 1960s, experimental work on molecules under screening as coronary dilators
allowed the discovery of the mechanism of calcium entry blockade by drugs later named …

Background When a patient arrives in the emergency department following a stroke, a
traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help …