Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of
diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous …

The term interferon describes a family of proteins consisting of three major types (I, II, III)
which differ in their primary protein sequences, cognate receptors, genetic loci, and cell …

Abstract Objective CD40–CD40 ligand (CD40L) interactions play a significant role in the
production of autoantibodies and tissue injury in lupus nephritis. We performed an open …

Systemic lupus erythematosus (SLE) is a typical autoimmune disease with a complex
pathogenesis and genetic predisposition. With continued understanding of this disease, it …

Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown origin affecting
virtually all organ systems. Beyond genetic and environmental factors, cytokine imbalances …

Indirect evidence suggests that type-I interferons (IFN-α/β) play a significant role in the
pathogenesis of lupus. To directly examine the contribution of these pleiotropic molecules …

Spontaneously developed germinal centers (GCs [Spt-GCs]) harbor autoreactive B cells that
generate somatically mutated and class-switched pathogenic autoantibodies (auto-Abs) to …

Overactivity of the germinal center (GC) pathway resulting from accumulation of follicular
helper T (Tfh) cells causes autoimmunity, underscoring the need to understand the factors …

Objective To study the contribution of interferon‐α (IFNα) and IFNγ to the IFN gene
expression signature that has been observed in microarray screens of peripheral blood …

SLE is an autoimmune inflammatory disease in which various pro‐and anti‐inflammatory
cytokines, including TGF‐β, IL‐10, BAFF, IL‐6, IFN‐α, IFN‐γ, IL‐17, and IL‐23, play crucial …