Mitochondria are key players in the generation and regulation of cellular bioenergetics,
producing the majority of adenosine triphosphate molecules by the oxidative …

The search for genes in bipolar disorder has provided numerous genetic loci that have been
linked to susceptibility to developing the disorder. However, because of the genetic …

Platelets play an important role not only in hemostasis but also in the pathophysiology of
coronary artery disease. The complex interactions among the vascular endothelium …

Previous human postmortem brain tissue research has implicated abnormalities of 5-HT
receptor availability in depression and suicide. Although altered abundance of 5-HT 1A, 5 …

Bipolar disorder (BD) has been a particularly challenging illness for the development of
adequate animal models for neurobiological studies. These difficulties are largely related to …

Mood disorders are among the most prevalent and recurrent forms of psychiatric illnesses. In
the last decade, there has been increased understanding of the biological basis of mood …

The purinergic system, which includes the anticonvulsant and antikindling neuromodulator
adenosine and the neurotransmitter ATP, modulates second messenger systems …

Dissecting trait neurobiological abnormalities in bipolar disorder (BD) from those
characterizing episodes of mood disturbance will help elucidate the aetiopathogenesis of …

The current pathophysiological understanding of mechanisms leading to onset and
progression of bipolar manic episodes remains limited. At the same time, available animal …

Bipolar disorder is one of the most severely debilitating of all medical illnesses. It can lead to
significant suffering for patients and their families, limit functioning and workplace …