Second harmonic generation (SHG) microscopy is an important optical imaging technique in
a variety of applications. This article describes the history and physical principles of SHG …

Impaired wound healing is one of the unsolved problems of modern medicine, affecting
patients' quality of life and causing serious economic losses. Impaired wound healing can …

Renal fibrosis, a common pathological manifestation of virtually all types of chronic kidney
disease (CKD), often results in diffuse kidney scarring and predisposes to end-stage renal …

Cancers are complex ecosystems composed of malignant cells embedded in an intricate
microenvironment made of different non-transformed cell types and extracellular matrix …

Multiphoton microscopy has recently passed the milestone of its first 30 years of activity in
biomedical research. The growing interest around this approach has led to a variety of …

Biological tissues are not uniquely composed of cells. A substantial part of their volume is
extracellular space, which is primarily filled by an intricate network of macromolecules …

The lungs are affected by illnesses including asthma, chronic obstructive pulmonary
disease, and infections such as influenza and SARS-CoV-2. Physiologically relevant models …

Second harmonic generation (SHG) and third harmonic generation (THG) microscopies
have emerged as powerful imaging modalities to examine structural properties of a wide …

The worldwide prevalence of non-alcoholic steatohepatitis (NASH) is increasing, causing a
significant medical burden, but no approved therapeutics are currently available. NASH drug …

The extracellular matrix is a key component of tissues, yet it is underrepresented in
proteomic datasets. Identification and evaluation of proteins in the extracellular matrix (ECM) …