A remarkable characteristic of majority of cancer cells is that, they fail to undergo apoptosis,
which in turn confers them a survival advantage over normal cells. Targeted cancer therapy …

Cancer is a leading cause of human death throughout the world. The lack of specificity
associated with conventional anti-cancer therapeutics leads to several side effects in …

Nonhomologous DNA end joining (NHEJ) is the major DNA double‐strand break (DSB)
repair pathway in mammals. Previously, we have described a small molecule inhibitor, SCR …

It has been demonstrated that MMP13 enzyme is related to most cancer cell tumors. The
world's largest traditional Chinese medicine database was applied to screen for structure …

Apoptosis is a highly regulated pathway of programmed cell death relying on the fine
balance between pro and antiapoptotic binding partners. Overexpression of the …

Bcl-2 protein is involved in cell apoptosis and is considered an interesting target for anti-
cancer therapy. The present study aims to understand the stability and conformational …

Simple Summary Adenoid cystic carcinoma of the lacrimal gland is a rare but aggressive
cancer with poor long-term prognosis. Due to the rarity of this cancer, little is understood …

Cholangiocarcinoma (CCA), an aggressive malignancy arising from the biliary epithelium,
exhibits a high incidence in Thailand. CCA usually lacks specific symptoms and is typically …

A chemical inhibitor of antiapoptotic protein, BCL2, known as Disarib, suffers poor solubility
in aqueous environments; thereby limiting its potential as a chemotherapeutic agent. To …

Bcl-2-protein family members are essential regulators of apoptosis. Anti-apoptotic Bcl-2
proteins ensure cell survival via different mechanisms, including via binding of pro-apoptotic …