Stand up to stand out: natural dietary polyphenols curcumin, resveratrol, and gossypol as potential therapeutic candidates against severe acute respiratory syndrome …

Z Wang, X Song, W Xu, S Lei, H Zhang, L Yang - Nutrients, 2023 - mdpi.com
The COVID-19 pandemic has stimulated collaborative drug discovery efforts in academia
and the industry with the aim of developing therapies and vaccines that target SARS-CoV-2 …

Antiviral potential of plants against COVID-19 during outbreaks—An update

QMS Jamal - International Journal of Molecular Sciences, 2022 - mdpi.com
Several human diseases are caused by viruses, including cancer, Type I diabetes,
Alzheimer's disease, and hepatocellular carcinoma. In the past, people have suffered greatly …

Study of MDM2 as Prognostic Biomarker in Brain-LGG Cancer and Bioactive Phytochemicals Inhibit the p53-MDM2 Pathway: A Computational Drug Development …

P Biswas, S Bibi, Q Yousafi, A Mehmood, S Saleem… - Molecules, 2023 - mdpi.com
An evaluation of the expression and predictive significance of the MDM2 gene in brain lower-
grade glioma (LGG) cancer was carried out using onco-informatics pipelines. Several …

Molecular Dynamics Simulation and Pharmacoinformatic Integrated Analysis of Bioactive Phytochemicals from Azadirachta indica (Neem) to Treat Diabetes Mellitus

A Abdullah, P Biswas, M Sahabuddin… - Journal of …, 2023 - Wiley Online Library
Diabetes mellitus is a chronic hormonal and metabolic disorder in which our body cannot
generate necessary insulin or does not act in response to it, accordingly, ensuing in …

Application of molecular dynamics simulation for exploring the roles of plant biomolecules in promoting environmental health

J Wu, T Gao, H Guo, L Zhao, S Lv, J Lv, R Yao… - Science of The Total …, 2023 - Elsevier
Understanding the dynamic changes of plant biomolecules is vital for exploring their
mechanisms in the environment. Molecular dynamics (MD) simulation has been widely used …

MasitinibL shows promise as a drug-like analog of masitinib that elicits comparable SARS-Cov-2 3CLpro inhibition with low kinase preference

OA Durojaye, NO Okoro, AS Odiba, BC Nwanguma - Scientific Reports, 2023 - nature.com
SARS-CoV-2 infection has led to several million deaths worldwide and ravaged the
economies of many countries. Hence, developing therapeutics against SARS-CoV-2 …

Exploring the aroma profile and biomedical applications of Scutellaria nuristanica Rech. F.: A new insight as a natural remedy

M Shah, M Shahab, S Ullah, S Bibi, NU Rahman… - Phytomedicine, 2024 - Elsevier
Abstract Background The Scutellaria genus has promising therapeutic capabilities as an
aromatherapy. Based on that and local practices of S. nuristanica Rech. F. The essential oil …

[HTML][HTML] Ganoderma microsporum immunomodulatory protein acts as a multifunctional broad-spectrum antiviral against SARS-CoV-2 by interfering virus binding to the …

HPT Ho, TY Lin, JN Hung, YH Chiu, MH Tsai - Biomedicine & …, 2022 - Elsevier
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly
transmissible coronavirus that has caused over 6 million fatalities. SARS-CoV-2 variants …

Exploring the potential of black soldier Fly larval proteins as bioactive peptide sources through in silico gastrointestinal proteolysis: a cheminformatic investigation

FC Wong, YH Lee, JH Ong, FA Manan, MZ Sabri… - Catalysts, 2023 - mdpi.com
Despite their potential as a protein source for human consumption, the health benefits of
black soldier fly larvae (BSFL) proteins following human gastrointestinal (GI) digestion are …

[HTML][HTML] A comprehensive perspective of traditional Arabic or Islamic medicinal plants as an adjuvant therapy against COVID-19

SI Ahmed, S Jamil, H Ismatullah, R Hussain… - Saudi Journal of …, 2023 - Elsevier
COVID-19 is a pulmonary disease caused by SARS-CoV-2. More than 200 million
individuals are infected by this globally. Pyrexia, coughing, shortness of breath, headaches …