Insects possess a cuticle that covers all tissues exposed to the outside world including the
body, the fore-and hindgut and the luminal side of the tracheae. The cuticle is a …

A large body of evidence indicates that genome annotation pipelines have biased our view
of coding sequences because they generally undersample small proteins and peptides. The …

In animals, Hox transcription factors define regional identity in distinct anatomical domains.
How Hox genes encode this specificity is a paradox, because different Hox proteins bind …

Genes include cis-regulatory regions that contain transcriptional enhancers. Recent reports
have shown that developmental genes often possess multiple discrete enhancer modules …

A substantial proportion of eukaryotic transcripts are considered to be noncoding RNAs
because they contain only short open reading frames (sORFs). Recent findings suggest …

Despite recent advances in developmental biology, and the sequencing and annotation of
genomes, key questions regarding the organisation of cells into embryos remain. One …

One central, and yet unsolved, question in evolutionary biology is the relationship between
the genetic variants segregating within species and the causes of morphological differences …

Transcriptome analyses in eukaryotes, including mice and humans, have identified polyA-
containing transcripts that lack long open reading frames (ORFs;> 100 amino acids),. These …

We previously showed in Drosophila melanogaster embryos that low-affinity Ultrabithorax
(Ubx)-responsive shavenbaby (svb) enhancers drive expression using localized …

During epithelial tissue morphogenesis, developmental progenitor cells undergo dynamic
adhesive and cytoskeletal remodeling to trigger proliferation and migration. Transcriptional …