The fact that not all individuals exposed to the same environmental risk factors develop
obesity supports the hypothesis of the existence of underlying genetic and epigenetic …

Alzheimer's disease (AD) is the most common type of dementia characterized by the
deposition of amyloid beta (Aβ) plaques and tau-neurofibrillary tangles in the brain. Visceral …

Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …

Significance: Hypoxia is emerging as a crucial regulator of the tumor microenvironment; it
governs the metastatic potential of multiple primary cancers. It is also potentially involved in …

To better understand the mechanisms at the basis of neutrophil functions during SARS‐CoV‐
2, we studied patients with severe COVID‐19 pneumonia. They had high blood proportion of …

Adipose, or fat, tissue (AT) was once considered an inert tissue that primarily existed to store
lipids, and was not historically recognized as an important organ in the regulation and …

Genetic effects on gene expression and splicing can be modulated by cellular and
environmental factors; yet interactions between genotypes, cell type, and treatment have not …

The interest on a potential association between cancer and sleep-disordered breathing
(SDB) has clearly gained substantial traction over the last several years. This novel …

Because of the enduring rise in the prevalence of obesity worldwide, there is continued
interest in hypoxia as a mechanism underlying the pathophysiology of obesity and its …

Male reproductive functions, which include testicular steroidogenesis, spermatogenesis, and
sexual/erectile functions are key in male fertility, but may be adversely altered by several …