Transition metals are required trace elements for all forms of life. Due to their unique
inorganic and redox properties, transition metals serve as cofactors for enzymes and other …

Mycobacterium tuberculosis is a facultative intracellular pathogen that thrives inside host
macrophages. A key trait of M. tuberculosis is to exploit and manipulate metal cation …

Lactoferrin (Lf), existing widely in human and mammalian milk, is a multifunctional
glycoprotein with many functions, such as immune regulation, anti-inflammation …

Microbes exert a major impact on human health and disease by either promoting or
disrupting homeostasis, in the latter instance leading to the development of infectious …

Due to the emergence of multidrug-resistant pathogens, it is necessary to develop options to
fight infections caused by these agents. Lactoferrin (Lf) is a cationic nonheme multifunctional …

Iron (Fe) is an essential micronutrient for both microbes and their hosts. The biologic
importance of Fe derives from its inherent ability to act as a universal redox catalyst, co …

The emergence of new infectious diseases poses a major threat to humans, animals, and
broader ecosystems. Defining factors that govern the ability of pathogens to adapt to new …

The overuse of broad-spectrum antibiotics rapidly selects for dangerous multi-drug resistant
bacterial pathogens. The landscape of antibiotic drug discovery is adapting to this wave of …

Lipoproteins decorate the surface of many Gram-negative bacterial pathogens, playing
essential roles in immune evasion and nutrient acquisition. In Neisseria spp., the causative …

Iron is an essential micronutrient for nearly all living organisms. In addition to facilitating
redox reactions, iron is bound by metalloproteins that participate in a variety of biological …