New designs for phototherapeutic transition metal complexes
In this Minireview, we highlight recent advances in the design of transition metal complexes
for photodynamic therapy (PDT) and photoactivated chemotherapy (PACT), and discuss the …
for photodynamic therapy (PDT) and photoactivated chemotherapy (PACT), and discuss the …
Diazido platinum (IV) complexes for photoactivated anticancer chemotherapy
H Shi, C Imberti, PJ Sadler - Inorganic Chemistry Frontiers, 2019 - pubs.rsc.org
Diazido Pt (IV) complexes with a general formula [Pt (N3) 2 (L)(L′)(OR)(OR′)] are a new
generation of anticancer prodrugs designed for use in photoactivated chemotherapy. The …
generation of anticancer prodrugs designed for use in photoactivated chemotherapy. The …
Photo‐Reduction with NIR Light of Nucleus‐Targeting PtIV Nanoparticles for Combined Tumor‐Targeted Chemotherapy and Photodynamic Immunotherapy
D Wei, Y Huang, B Wang, L Ma… - Angewandte Chemie …, 2022 - Wiley Online Library
The development of PtIV prodrugs which are selectively reduced within cancerous cells into
their PtII therapeutically active species has received increasing attention within the last …
their PtII therapeutically active species has received increasing attention within the last …
Reduction of Platinum (IV) Prodrug Hemoglobin Nanoparticles with Deeply Penetrating Ultrasound Radiation for Tumor‐Targeted Therapeutically Enhanced …
The development of PtIV prodrugs that are reduced into the therapeutically active PtII
species within the tumor microenvironment has received much research interest. In order to …
species within the tumor microenvironment has received much research interest. In order to …
A Multi‐action and Multi‐target RuII–PtIV Conjugate Combining Cancer‐Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers
PtII complexes are commonly used to treat cancer. To reduce their side effects and improve
their pharmacological properties, PtIV complexes are being developed as prodrug …
their pharmacological properties, PtIV complexes are being developed as prodrug …
Single-cell chemistry of photoactivatable platinum anticancer complexes
EM Bolitho, C Sanchez-Cano, H Shi… - Journal of the …, 2021 - ACS Publications
The Pt (IV) prodrug trans, trans, trans-[Pt (pyridine) 2 (N3) 2 (OH) 2](Pt1) and its coumarin
derivative trans, trans, trans-[Pt (pyridine) 2 (N3) 2 (OH)(coumarin-3-carboxylate)](Pt2) are …
derivative trans, trans, trans-[Pt (pyridine) 2 (N3) 2 (OH)(coumarin-3-carboxylate)](Pt2) are …
Induction of immunogenic cell death in cancer cells by a photoactivated platinum (IV) prodrug
V Novohradsky, J Pracharova, J Kasparkova… - Inorganic chemistry …, 2020 - pubs.rsc.org
The platinum (IV) prodrug trans, trans, trans-[Pt (N3) 2 (OH) 2 (py) 2](1) is stable and non-
toxic in the dark, but potently cytotoxic to cancer cells when irradiated by visible light …
toxic in the dark, but potently cytotoxic to cancer cells when irradiated by visible light …
Approaches towards understanding the mechanism-of-action of metallodrugs
Known as highly efficient metallodrugs that have been clinically used to treat various types
of cancers, cisplatin and its analogues have attracted and inspired extensive interest in the …
of cancers, cisplatin and its analogues have attracted and inspired extensive interest in the …
Metal ion binding to the amyloid β monomer studied by native top-down FTICR mass spectrometry
Native top-down mass spectrometry is a fast, robust biophysical technique that can provide
molecular-scale information on the interaction between proteins or peptides and ligands …
molecular-scale information on the interaction between proteins or peptides and ligands …
Critical discussion of the applications of metal complexes for 2-photon photodynamic therapy
Photodynamic therapy is a light-activated medical technique, which has received increasing
attention within the last decade to treat various diseases including bacterial, viral or fungal …
attention within the last decade to treat various diseases including bacterial, viral or fungal …