The liver as an endocrine organ—linking NAFLD and insulin resistance

MJ Watt, PM Miotto, W De Nardo… - Endocrine …, 2019 - academic.oup.com
The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …

[HTML][HTML] Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

AL Cardoso, A Fernandes, JA Aguilar-Pimentel… - Ageing research …, 2018 - Elsevier
Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

[HTML][HTML] Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations

Y Ni, L Qian, SL Siliceo, X Long, E Nychas, Y Liu… - Cell Metabolism, 2023 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic dysfunction
for which effective interventions are lacking. To investigate the effects of resistant starch (RS) …

Risk assessment with gut microbiome and metabolite markers in NAFLD development

H Leung, X Long, Y Ni, L Qian, E Nychas… - Science translational …, 2022 - science.org
A growing body of evidence suggests interplay between the gut microbiota and the
pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, the role of the gut …

[HTML][HTML] FGF21: an emerging therapeutic target for non-alcoholic steatohepatitis and related metabolic diseases

EJ Tillman, T Rolph - Frontiers in endocrinology, 2020 - frontiersin.org
The rising global prevalence of obesity, metabolic syndrome, and type 2 diabetes has driven
a sharp increase in non-alcoholic fatty liver disease (NAFLD), characterized by excessive fat …

[HTML][HTML] An integrated understanding of the rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis in humans

A Mardinoglu, H Wu, E Bjornson, C Zhang… - Cell metabolism, 2018 - cell.com
A carbohydrate-restricted diet is a widely recommended intervention for non-alcoholic fatty
liver disease (NAFLD), but a systematic perspective on the multiple benefits of this diet is …

Understanding the physiology of FGF21

FM Fisher, E Maratos-Flier - Annual review of physiology, 2016 - annualreviews.org
Fibroblast growth factor 21 (FGF21) is a peptide hormone that is synthesized by several
organs and regulates energy homeostasis. Excitement surrounding this relatively recently …

Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications

SM Francque, D Van Der Graaff, WJ Kwanten - Journal of hepatology, 2016 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become one of the most frequent chronic liver
diseases in the Western society and its prevalence is likely to rise even further. An …

Mechanisms of weight loss after obesity surgery

E Akalestou, AD Miras, GA Rutter… - Endocrine …, 2022 - academic.oup.com
Obesity surgery remains the most effective treatment for obesity and its complications.
Weight loss was initially attributed to decreased energy absorption from the gut but has …

[HTML][HTML] Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

S Byun, S Seok, YC Kim, Y Zhang, P Yau… - Nature …, 2020 - nature.com
Autophagy is essential for cellular survival and energy homeostasis under nutrient
deprivation. Despite the emerging importance of nuclear events in autophagy regulation …