The liver as an endocrine organ—linking NAFLD and insulin resistance
MJ Watt, PM Miotto, W De Nardo… - Endocrine …, 2019 - academic.oup.com
The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …
[HTML][HTML] Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
AL Cardoso, A Fernandes, JA Aguilar-Pimentel… - Ageing research …, 2018 - Elsevier
Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …
valuable method for identifying elderly people at risk for increased vulnerability, disease …
[HTML][HTML] Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations
Y Ni, L Qian, SL Siliceo, X Long, E Nychas, Y Liu… - Cell Metabolism, 2023 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic dysfunction
for which effective interventions are lacking. To investigate the effects of resistant starch (RS) …
for which effective interventions are lacking. To investigate the effects of resistant starch (RS) …
Risk assessment with gut microbiome and metabolite markers in NAFLD development
H Leung, X Long, Y Ni, L Qian, E Nychas… - Science translational …, 2022 - science.org
A growing body of evidence suggests interplay between the gut microbiota and the
pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, the role of the gut …
pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, the role of the gut …
[HTML][HTML] FGF21: an emerging therapeutic target for non-alcoholic steatohepatitis and related metabolic diseases
EJ Tillman, T Rolph - Frontiers in endocrinology, 2020 - frontiersin.org
The rising global prevalence of obesity, metabolic syndrome, and type 2 diabetes has driven
a sharp increase in non-alcoholic fatty liver disease (NAFLD), characterized by excessive fat …
a sharp increase in non-alcoholic fatty liver disease (NAFLD), characterized by excessive fat …
[HTML][HTML] An integrated understanding of the rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis in humans
A carbohydrate-restricted diet is a widely recommended intervention for non-alcoholic fatty
liver disease (NAFLD), but a systematic perspective on the multiple benefits of this diet is …
liver disease (NAFLD), but a systematic perspective on the multiple benefits of this diet is …
Understanding the physiology of FGF21
FM Fisher, E Maratos-Flier - Annual review of physiology, 2016 - annualreviews.org
Fibroblast growth factor 21 (FGF21) is a peptide hormone that is synthesized by several
organs and regulates energy homeostasis. Excitement surrounding this relatively recently …
organs and regulates energy homeostasis. Excitement surrounding this relatively recently …
Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications
SM Francque, D Van Der Graaff, WJ Kwanten - Journal of hepatology, 2016 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become one of the most frequent chronic liver
diseases in the Western society and its prevalence is likely to rise even further. An …
diseases in the Western society and its prevalence is likely to rise even further. An …
Mechanisms of weight loss after obesity surgery
Obesity surgery remains the most effective treatment for obesity and its complications.
Weight loss was initially attributed to decreased energy absorption from the gut but has …
Weight loss was initially attributed to decreased energy absorption from the gut but has …
[HTML][HTML] Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase
Autophagy is essential for cellular survival and energy homeostasis under nutrient
deprivation. Despite the emerging importance of nuclear events in autophagy regulation …
deprivation. Despite the emerging importance of nuclear events in autophagy regulation …