Acute lung injury (ALI) and its more severe form acute respiratory distress syndrome (ARDS)
are life-threatening diseases that are characterized by acute onset, pulmonary inflammation …

The generation of reactive oxygen species (ROS) plays an important role for the
maintenance of cellular processes and functions in the body. However, the excessive …

Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory
failure due to acute respiratory distress syndrome (ARDS). Paradoxically, mechanical …

The most common pediatric mitochondrial disease is Leigh syndrome, an episodic,
subacute neurodegeneration that can lead to death within the first few years of life, for which …

Acute respiratory distress syndrome (ARDS) is a major cause of respiratory failure, with
limited effective treatments available. Alveolar macrophages participate in the pathogenesis …

The aim of this study was to investigate the changes induced by high tidal volume ventilation
(HVTV) in pulmonary expression of micro-RNAs (miRNAs) and identify potential target …

Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory
failure due to acute respiratory distress syndrome (ARDS), a refractory lung disease with an …

Background The antiinflammatory effects of hydrogen sulfide (H2S) and sodium sulfide
(Na2S) treatment may prevent acute lung injury induced by high tidal volume (HVT) …

Significance: Oxidative stress in the cell is characterized by excessive generation of reactive
oxygen species (ROS). Superoxide (O2−) and hydrogen peroxide (H2O2) are the main ROS …

Intraoperative ventilation settings can affect postoperative pul-monary outcomes. Many
patients have short-term mechanical ventilation (MV) with large tidal volumes (VT> 10 mL/kg …