The development of targeted medicine has greatly expanded treatment options and spurred
new research avenues in cancer therapeutics, with monoclonal antibodies (mAbs) emerging …

Recombinant antibodies are highly specific detection probes in research, diagnostics, and
have emerged over the last two decades as the fastest growing class of therapeutic proteins …

Tumor targeting is a booming business: The global therapeutic monoclonal antibody market
accounted for more than $78 billion in 2012 and is expanding exponentially. Tumors can be …

Highlights•Nucleolin is overexpressed at the surface cancer cells and tumor
vasculature.•Nucleolin enables dual cellular targeting strategies.•Surface nucleolin as a …

Antibodies and related proteins comprise one of the largest and fastest-growing classes of
protein pharmaceuticals. A majority of such molecules are monoclonal antibodies; however …

Single-domain antibodies are the smallest antigen-binding units of antibodies, consisting
either only of one variable domain or one engineered constant domain that solely facilitates …

The internal organs embedded in the cavities are lined by an epithelial monolayer termed
the mesothelium. The mesothelium is increasingly implicated in driving various internal …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is a trimer of
S1/S2 heterodimers with three receptor-binding domains (RBDs) at the S1 subunit for …

The immune system is essential in recognizing and eliminating tumor cells. The unique
characteristics of the tumor microenvironment (TME), such as heterogeneity, reduced blood …

Introduction: Peritoneal dissemination is a particular form of malignant progression in
ovarian cancer, preceding hematogenic or lymphatic dissemination. Thus, prevention of …