The phospholipase A2 superfamily as a central hub of bioactive lipids and beyond

M Murakami - Pharmacology & therapeutics, 2023 - Elsevier
Abstract In essence,“phospholipase A 2”(PLA 2) means a group of enzymes that release
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …

α/β-Hydrolase domain (ABHD) inhibitors as new potential therapeutic options against lipid-related diseases

G Bononi, T Tuccinardi, F Rizzolio… - Journal of medicinal …, 2021 - ACS Publications
Much of the experimental evidence in the literature has linked altered lipid metabolism to
severe diseases such as cancer, obesity, cardiovascular pathologies, diabetes, and …

High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss

M Siersbæk, L Varticovski, S Yang, S Baek… - Scientific Reports, 2017 - nature.com
Epigenetic factors have been suggested to play an important role in metabolic memory by
trapping and maintaining initial metabolic changes within the transcriptional regulatory …

Single-cell analysis reveals urothelial cell heterogeneity and regenerative cues following cyclophosphamide-induced bladder injury

X Cheng, H Lai, W Luo, M Zhang, J Miao, W Song… - Cell Death & …, 2021 - nature.com
Cyclophosphamide is a commonly used chemotherapeutic drug to treat cancer with side
effects that trigger bladder injury and hemorrhagic cystitis. Although previous studies have …

A maize triacylglycerol lipase inhibits sugarcane mosaic virus infection

XJ Xu, C Geng, SY Jiang, Q Zhu, ZY Yan… - Plant …, 2022 - academic.oup.com
Triacylglycerol lipase (TGL) plays critical roles in providing energy for seed germination and
plant development. However, the role of TGL in regulating plant virus infection is largely …

Sequence analysis and structure prediction of ABHD16A and the roles of the ABHD family members in human disease

J Xu, W Gu, K Ji, Z Xu, H Zhu, W Zheng - Open biology, 2018 - royalsocietypublishing.org
Abhydrolase domain containing 16A (ABHD16A) is a member of the α/β hydrolase domain-
containing (ABHD) protein family and is expressed in a variety of animal cells. Studies have …

Many or too many progesterone membrane receptors? Clinical implications

A Wendler, M Wehling - Trends in Endocrinology & Metabolism, 2022 - cell.com
Several receptors for nongenomically initiated actions of progesterone (P4) exist, namely
membrane-associated P4 receptors (MAPRs), membrane progestin receptors (mPRs) …

Endocannabinoid turnover

CJ Fowler, P Doherty, SPH Alexander - Advances in Pharmacology, 2017 - Elsevier
In this review, we consider the biosynthetic, hydrolytic, and oxidative metabolism of the
endocannabinoids anandamide and 2-arachidonoylglycerol. We describe the enzymes …

Membrane cholesterol inhibits progesterone-mediated sperm function through the possible involvement of ABHD2

L De Toni, I Cosci, I Sabovic, A Di Nisio… - International Journal of …, 2023 - mdpi.com
Abhydrolase domain containing 2-acylglycerol lipase (ABHD2) was recently claimed as the
membrane receptor of progesterone (P4) in sperm cells, mediating cell processes such as …

Elucidating the functional role of human ABHD16B lipase in regulating triacylglycerol mobilization and membrane lipid synthesis in Saccharomyces cerevisiae

R Narayanasamy, D Usharani… - Chemistry and Physics of …, 2024 - Elsevier
Lipids are essential biological macromolecules that play a pivotal role in various
physiological processes and cellular homeostasis. ABHD16B, a member of the α/β …