PI (4, 5) P2-binding effector proteins for vesicle exocytosis
TFJ Martin - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2015 - Elsevier
Abstract PI (4, 5) P 2 participates directly in priming and possibly in fusion steps of Ca 2+-
triggered vesicle exocytosis. High concentration nanodomains of PI (4, 5) P 2 reside on the …
triggered vesicle exocytosis. High concentration nanodomains of PI (4, 5) P 2 reside on the …
Models of synaptotagmin‐1 to trigger Ca2+‐dependent vesicle fusion
Y Park, JK Ryu - FEBS letters, 2018 - Wiley Online Library
Vesicles in neurons and neuroendocrine cells store neurotransmitters and peptide
hormones, which are released by vesicle fusion in response to Ca2+‐evoking stimuli …
hormones, which are released by vesicle fusion in response to Ca2+‐evoking stimuli …
Phosphatidylinositol 4, 5-bisphosphate clusters act as molecular beacons for vesicle recruitment
A Honigmann, G Van Den Bogaart, E Iraheta… - Nature structural & …, 2013 - nature.com
Synaptic-vesicle exocytosis is mediated by the vesicular Ca2+ sensor synaptotagmin-1.
Synaptotagmin-1 interacts with the SNARE protein syntaxin-1A and acidic phospholipids …
Synaptotagmin-1 interacts with the SNARE protein syntaxin-1A and acidic phospholipids …
Forming giant vesicles with controlled membrane composition, asymmetry, and contents
Growing knowledge of the key molecular components involved in biological processes such
as endocytosis, exocytosis, and motility has enabled direct testing of proposed mechanistic …
as endocytosis, exocytosis, and motility has enabled direct testing of proposed mechanistic …
HOPS initiates vacuole docking by tethering membranes before trans-SNARE complex assembly
CM Hickey, W Wickner - Molecular Biology of the Cell, 2010 - Am Soc Cell Biol
Vacuole homotypic fusion has been reconstituted with all purified components: vacuolar
lipids, four soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) …
lipids, four soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) …
[HTML][HTML] Synaptotagmin-1 interacts with PI (4, 5) P2 to initiate synaptic vesicle docking in hippocampal neurons
Synaptic vesicle (SV) docking is a dynamic multi-stage process that is required for efficient
neurotransmitter release in response to nerve impulses. Although the steady-state SV …
neurotransmitter release in response to nerve impulses. Although the steady-state SV …
Minimal membrane docking requirements revealed by reconstitution of Rab GTPase-dependent membrane fusion from purified components
Rab GTPases and their effectors mediate docking, the initial contact of intracellular
membranes preceding bilayer fusion. However, it has been unclear whether Rab proteins …
membranes preceding bilayer fusion. However, it has been unclear whether Rab proteins …
Conflicting views on the membrane fusion machinery and the fusion pore
JB Sørensen - Annual Review of Cell and Developmental, 2009 - annualreviews.org
Fast exocytosis of synaptic vesicles differs from other membrane fusion reactions by being
under tight temporal control by the intracellular calcium concentration. This is achieved by …
under tight temporal control by the intracellular calcium concentration. This is achieved by …
Mechanism and function of synaptotagmin-mediated membrane apposition
Abstract Synaptotagmin-1 is a Ca2+ sensor that triggers synchronous neurotransmitter
release. The first documented biochemical property of synaptotagmin-1 was its ability to …
release. The first documented biochemical property of synaptotagmin-1 was its ability to …
Solution single‐vesicle assay reveals PIP2‐mediated sequential actions of synaptotagmin‐1 on SNAREs
Synaptotagmin‐1 (Syt1) is a major Ca2+ sensor for synchronous neurotransmitter release,
which requires vesicle fusion mediated by SNAREs (soluble N‐ethylmaleimide‐sensitive …
which requires vesicle fusion mediated by SNAREs (soluble N‐ethylmaleimide‐sensitive …