cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging
CRR Schmitz, RM Maurmann, FTCR Guma… - Frontiers in …, 2023 - frontiersin.org
Aging is associated with an increased incidence of autoimmune diseases, despite the
progressive decline of immune responses (immunosenescence). This apparent paradox can …
progressive decline of immune responses (immunosenescence). This apparent paradox can …
Single-cell omics traces the heterogeneity of prostate cancer cells and the tumor microenvironment
X Yu, R Liu, W Gao, X Wang, Y Zhang - Cellular & Molecular Biology …, 2023 - Springer
Prostate cancer is one of the more heterogeneous tumour types. In recent years, with the
rapid development of single-cell sequencing and spatial transcriptome technologies …
rapid development of single-cell sequencing and spatial transcriptome technologies …
The role of tissue-resident memory T cells as mediators for response and toxicity in immunotherapy-treated melanoma—two sides of the same coin?
Tissue-resident memory T cells (TRM cells) have become an interesting subject of study for
antitumor immunity in melanoma and other solid tumors. In the initial phases of antitumor …
antitumor immunity in melanoma and other solid tumors. In the initial phases of antitumor …
Chemokines and Cytokines in Immunotherapy of Melanoma and Other Tumors: From Biomarkers to Therapeutic Targets
Chemokines and cytokines represent an emerging field of immunotherapy research. They
are responsible for the crosstalk and chemoattraction of immune cells and tumor cells. For …
are responsible for the crosstalk and chemoattraction of immune cells and tumor cells. For …
Intratumoral dendritic cells and T cells predict survival in gastroenteropancreatic neuroendocrine neoplasms
W Werner, K Detjen, A Bruneau, I Lurje… - Endocrine-Related …, 2023 - erc.bioscientifica.com
Clinical management of gastroenteropancreatic neuroendocrine neoplasms remains
challenging. We recently introduced the FMS-like tyrosine kinase 3 ligand (FLT3LG) as a …
challenging. We recently introduced the FMS-like tyrosine kinase 3 ligand (FLT3LG) as a …
Macrophage Inflammatory Proteins (MIPs) Contribute to Malignant Potential of Colorectal Polyps and Modulate Likelihood of Cancerization Associated with Standard …
J Wierzbicki, I Bednarz-Misa, Ł Lewandowski… - International Journal of …, 2024 - mdpi.com
Better understanding of molecular changes leading to neoplastic transformation is
prerequisite to optimize risk assessment and chemopreventive and surveillance strategies …
prerequisite to optimize risk assessment and chemopreventive and surveillance strategies …
[HTML][HTML] MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan
L Morè, L Privitera, DD Cooper, M Tsogka… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Positive experiences, such as social interaction, cognitive training and physical exercise,
have been shown to ameliorate some of the harms to cognition associated with ageing …
have been shown to ameliorate some of the harms to cognition associated with ageing …
[HTML][HTML] Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation
M Alshebremi, SL Tomchuck, JT Myers… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Despite its potential utility in delivering direct tumor killing and in situ whole-cell
tumor vaccination, tumor cryoablation produces highly variable and unpredictable clinical …
tumor vaccination, tumor cryoablation produces highly variable and unpredictable clinical …
Blockade of EP4 by ASP7657 Modulates Myeloid Cell Differentiation In Vivo and Enhances the Antitumor Effect of Radiotherapy
T Nishibata, N Amino, R Tanaka-Kado… - BioMed Research …, 2023 - Wiley Online Library
The tumor microenvironment (TME) is thought to influence the antitumor efficacy of immuno‐
oncology agents through various products of both tumor and stromal cells. One immune …
oncology agents through various products of both tumor and stromal cells. One immune …
Correction: Reschke, R.; Olson, DJ Leveraging STING, Batf3 Dendritic Cells, CXCR3 Ligands, and Other Components Related to Innate Immunity to Induce a “Hot” …
Background: Open Access Correction Correction: Reschke, R.; Olson, DJ Leveraging
STING, Batf3 Dendritic Cells, CXCR3 Ligands, and Other Components Related to Innate …
STING, Batf3 Dendritic Cells, CXCR3 Ligands, and Other Components Related to Innate …