cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging

CRR Schmitz, RM Maurmann, FTCR Guma… - Frontiers in …, 2023 - frontiersin.org
Aging is associated with an increased incidence of autoimmune diseases, despite the
progressive decline of immune responses (immunosenescence). This apparent paradox can …

Single-cell omics traces the heterogeneity of prostate cancer cells and the tumor microenvironment

X Yu, R Liu, W Gao, X Wang, Y Zhang - Cellular & Molecular Biology …, 2023 - Springer
Prostate cancer is one of the more heterogeneous tumour types. In recent years, with the
rapid development of single-cell sequencing and spatial transcriptome technologies …

The role of tissue-resident memory T cells as mediators for response and toxicity in immunotherapy-treated melanoma—two sides of the same coin?

R Reschke, B Deitert, AH Enk, JC Hassel - Frontiers in Immunology, 2024 - frontiersin.org
Tissue-resident memory T cells (TRM cells) have become an interesting subject of study for
antitumor immunity in melanoma and other solid tumors. In the initial phases of antitumor …

Chemokines and Cytokines in Immunotherapy of Melanoma and Other Tumors: From Biomarkers to Therapeutic Targets

R Reschke, AH Enk, JC Hassel - International Journal of Molecular …, 2024 - mdpi.com
Chemokines and cytokines represent an emerging field of immunotherapy research. They
are responsible for the crosstalk and chemoattraction of immune cells and tumor cells. For …

Intratumoral dendritic cells and T cells predict survival in gastroenteropancreatic neuroendocrine neoplasms

W Werner, K Detjen, A Bruneau, I Lurje… - Endocrine-Related …, 2023 - erc.bioscientifica.com
Clinical management of gastroenteropancreatic neuroendocrine neoplasms remains
challenging. We recently introduced the FMS-like tyrosine kinase 3 ligand (FLT3LG) as a …

Macrophage Inflammatory Proteins (MIPs) Contribute to Malignant Potential of Colorectal Polyps and Modulate Likelihood of Cancerization Associated with Standard …

J Wierzbicki, I Bednarz-Misa, Ł Lewandowski… - International Journal of …, 2024 - mdpi.com
Better understanding of molecular changes leading to neoplastic transformation is
prerequisite to optimize risk assessment and chemopreventive and surveillance strategies …

[HTML][HTML] MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan

L Morè, L Privitera, DD Cooper, M Tsogka… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Positive experiences, such as social interaction, cognitive training and physical exercise,
have been shown to ameliorate some of the harms to cognition associated with ageing …

[HTML][HTML] Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation

M Alshebremi, SL Tomchuck, JT Myers… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Despite its potential utility in delivering direct tumor killing and in situ whole-cell
tumor vaccination, tumor cryoablation produces highly variable and unpredictable clinical …

Blockade of EP4 by ASP7657 Modulates Myeloid Cell Differentiation In Vivo and Enhances the Antitumor Effect of Radiotherapy

T Nishibata, N Amino, R Tanaka-Kado… - BioMed Research …, 2023 - Wiley Online Library
The tumor microenvironment (TME) is thought to influence the antitumor efficacy of immuno‐
oncology agents through various products of both tumor and stromal cells. One immune …

Correction: Reschke, R.; Olson, DJ Leveraging STING, Batf3 Dendritic Cells, CXCR3 Ligands, and Other Components Related to Innate Immunity to Induce a “Hot” …

R Reschke, DJ Olson - Cancers, 2024 - mdpi.com
Background: Open Access Correction Correction: Reschke, R.; Olson, DJ Leveraging
STING, Batf3 Dendritic Cells, CXCR3 Ligands, and Other Components Related to Innate …