The minimum inhibitory concentration of antibiotics: Methods, interpretation, clinical relevance

B Kowalska-Krochmal, R Dudek-Wicher - Pathogens, 2021 - mdpi.com
Inefficiency of medical therapies used in order to cure patients with bacterial infections
requires not only to actively look for new therapeutic strategies but also to carefully select …

Agents of last resort: an update on polymyxin resistance

Q Yang, JM Pogue, Z Li, RL Nation… - Infectious Disease …, 2020 - id.theclinics.com
The polymyxins, colistin (also known as polymyxin E) and polymyxin B, have a unique and
interesting history. Originally introduced in the 1950s for the treatment of infections owing to …

Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-Resistant Klebsiella pneumoniae Bacteremia and Abscess in a Liver Transplant Recipient

V Athans, EA Neuner, H Hassouna… - Antimicrobial agents …, 2019 - Am Soc Microbiol
We report a case of a 24-year-old liver transplant recipient who developed hepatic artery
thrombosis and graft failure, which was complicated by subphrenic abscess and persistent …

Pharmacokinetic characteristics of nebulized colistimethate sodium using two different types of nebulizers in critically ill patients with ventilator-associated respiratory …

A Kyriakoudi, K Pontikis, G Valsami, S Avgeropoulou… - Antibiotics, 2022 - mdpi.com
Background: Rising antimicrobial resistance has led to a revived interest in inhaled colistin
treatment in the critically ill patient with ventilator-associated respiratory infection (VARI) …

The New, New Daptomycin Breakpoint for Enterococcus spp

RM Humphries - Journal of Clinical Microbiology, 2019 - Am Soc Microbiol
ABSTRACT In 2019, the Clinical and Laboratory Standards Institute revised the daptomycin
breakpoints for Enterococcus spp. twice in rapid succession. Analyses leading to these …

[HTML][HTML] Aztreonam plus ceftazidime-avibactam as treatment of NDM-1-producing Klebsiella pneumoniae bacteraemia in a neutropenic patient: Last resort therapy?

P Bocanegra-Ibarias, A Camacho-Ortiz… - Journal of global …, 2020 - Elsevier
Objectives We report the successful treatment of a bloodstream infection caused by
Klebsiella pneumoniae harbouring NDM-1 using aztreonam-ceftazidime-avibactam in a …

Dose optimisation of antibiotics used for meningitis

AJ Heffernan, JA Roberts - Current Opinion in Infectious Diseases, 2021 - journals.lww.com
Clinicians should obtain the bacterial minimum inhibitory concentration when treating
patients with CNS Gram-negative bacterial infections and consider the underlying PK/PD …

Assessing clinical potential of old antibiotics against severe infections by multi-drug-resistant gram-negative bacteria using in silico modelling

P Paranos, S Vourli, S Pournaras, J Meletiadis - Pharmaceuticals, 2022 - mdpi.com
In the light of increasing antimicrobial resistance among gram-negative bacteria and the lack
of new more potent antimicrobial agents, new strategies have been explored. Old antibiotics …

[PDF][PDF] The Minimum Inhibitory Concentration of Antibiotics: Methods, Interpretation, Clinical Relevance. Pathogens 2021, 10, 165

B Kowalska-Krochmal, R Dudek-Wicher - 2021 - pdfs.semanticscholar.org
Inefficiency of medical therapies used in order to cure patients with bacterial infections
requires not only to actively look for new therapeutic strategies but also to carefully select …

Evaluation of the MicroScan Colistin Well and Gradient Diffusion Strips for Colistin Susceptibility Testing in Enterobacteriaceae

JD Lutgring, A Kim, D Campbell… - Journal of clinical …, 2019 - Am Soc Microbiol
Many laboratories are unable to perform colistin susceptibility testing. Diffusion-based
antimicrobial susceptibility testing methods are not recommended, and not all laboratories …