Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …

Since the discovery of the Escherichia coli leucine-responsive regulatory protein (Lrp)
almost 50 years ago, hundreds of Lrp homologs have been discovered, occurring in 45% of …

Primary metabolism plays a key role in the synthesis of secondary metabolite. In this study,
the main transcription factors in carbon, nitrogen, and phosphorus metabolisms (CcpA …

Streptomyces scabies is the best‐characterized plant‐pathogenic streptomycete, which is a
special species among the large genus Streptomyces. The pathogenicity of S. scabies relies …

Leucine-responsive regulatory proteins (Lrps) are a family of transcription factors involved in
diverse biological processes in bacteria. So far, molecular mechanism of Lrps for regulating …

Polyketides are one of the largest categories of secondary metabolites, and their
biosynthesis is initiated by polyketide synthases (PKSs) using coenzyme A esters of short …

Global regulator BldA, the only tRNA for a rare leucine codon UUA, is best known for its
ability to affect morphological differentiation and secondary metabolism in the genus …

Lincomycin industrially produced by Streptomyces lincolnensis can be adopted to treat
infections caused by Gram-positive bacteria. SLCG_Lrp, a transcriptional regulator of the Lrp …

Background Bitespiramycin (BT) is produced by recombinant spiramycin (SP) producing
strain Streptomyces spiramyceticus harboring a heterologous 4 ″-O-isovaleryltransferase …

Natural products of microbial origin have proven to be the wellspring of clinically useful
compounds for human therapeutics. Streptomyces species are predominant sources of …