Metabolomics and type 2 diabetes risk: an updated systematic review and meta-analysis of prospective cohort studies
BACKGROUND Due to the rapidly increasing availability of metabolomics data in
prospective studies, an update of the meta evidence on metabolomics and type 2 diabetes …
prospective studies, an update of the meta evidence on metabolomics and type 2 diabetes …
[HTML][HTML] Statins and risk of type 2 diabetes: mechanism and clinical implications
M Laakso, L Fernandes Silva - Frontiers in Endocrinology, 2023 - frontiersin.org
Statins are widely used to prevent cardiovascular disease events. Cardiovascular diseases
and type 2 diabetes are tightly connected since type 2 diabetes is a major risk factor for …
and type 2 diabetes are tightly connected since type 2 diabetes is a major risk factor for …
[HTML][HTML] Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis
V Miguel, J Tituaña, JI Herrero… - The Journal of …, 2021 - Am Soc Clin Investig
Chronic kidney disease (CKD) remains a major epidemiological, clinical, and biomedical
challenge. During CKD, renal tubular epithelial cells (TECs) present a persistent …
challenge. During CKD, renal tubular epithelial cells (TECs) present a persistent …
[HTML][HTML] High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies
Obesity and related metabolic diseases show clear sex-related differences. The growing
burden of these diseases calls for better understanding of the age-and sex-related metabolic …
burden of these diseases calls for better understanding of the age-and sex-related metabolic …
[HTML][HTML] Targeted metabolomics analysis of amino acids and acylcarnitines as risk markers for diabetes by LC–MS/MS technique
Diabetes is a common chronic disease affecting millions of people worldwide. It underlies
various complications and imposes many costs on individuals and society. Discovering early …
various complications and imposes many costs on individuals and society. Discovering early …
Effects of Mediterranean Diet on plasma metabolites and their relationship with insulin resistance and gut microbiota composition in a crossover randomized clinical …
S Galié, J García-Gavilán, C Papandreou… - Clinical Nutrition, 2021 - Elsevier
Summary Background & aims The Mediterranean Diet (MedDiet) may decrease the
cardiometabolic risk through modulation of metabolic pathways. Furthermore, the interplay …
cardiometabolic risk through modulation of metabolic pathways. Furthermore, the interplay …
[HTML][HTML] Fatty acid metabolites combine with reduced β oxidation to activate Th17 inflammation in human type 2 diabetes
Mechanisms that regulate metabolites and downstream energy generation are key
determinants of T cell cytokine production, but the processes underlying the Th17 profile that …
determinants of T cell cytokine production, but the processes underlying the Th17 profile that …
[HTML][HTML] Altered metabolome of lipids and amino acids species: a source of early signature biomarkers of T2DM
Diabetes mellitus, a disease of modern civilization, is considered the major mainstay of
mortalities around the globe. A great number of biochemical changes have been proposed …
mortalities around the globe. A great number of biochemical changes have been proposed …
[HTML][HTML] Changes in metabolomics profiles over ten years and subsequent risk of developing type 2 diabetes: results from the Nurses' Health Study
C Wittenbecher, M Guasch-Ferre, DE Haslam… - …, 2022 - thelancet.com
Background Metabolomics profiles were consistently associated with type 2 diabetes (T2D)
risk, but evidence on long-term metabolite changes and T2D incidence is lacking. We …
risk, but evidence on long-term metabolite changes and T2D incidence is lacking. We …
[HTML][HTML] Plasma metabolite profiles associated with the World Cancer Research Fund/American Institute for Cancer Research lifestyle score and future risk of …
Background A healthy lifestyle (HL) has been inversely related to type 2 diabetes (T2D) and
cardiovascular disease (CVD). However, few studies have identified a metabolite profile …
cardiovascular disease (CVD). However, few studies have identified a metabolite profile …