Background Neuromuscular disease causes a progressive decline in ventilatory function
which respiratory muscle training may address. Previous systematic reviews have focussed …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition noteworthy for upper
and lower motor neuron death. Involvement of respiratory motor neuron pools leads to …

Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative, and inevitably fatal
disease. There is no cure for ALS and life expectancy is typically 2–5 years after symptom …

Neuromuscular diseases are a heterogeneous group of neurologic diseases that affect a
number of neural structures including the motor nerves, neuromuscular junctions, or the …

Respiratory muscle weakness is a major cause of morbidity and mortality in patients with
neuromuscular diseases (NMDs). Respiratory involvement in NMDs can manifest broadly …

Hypoventilation and chronic hypercapnic respiratory failure are common sequelae of many
neuromuscular diseases (NMD) where respiratory muscle weakness is a feature, including …

Background Impaired cough results in airway secretion retention, atelectasis and
pneumonia in individuals with Duchenne muscular dystrophy (DMD). Lung volume …

Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder, with a prevalence of
15.9 to 19.5 per 100,000 live male births, 1 that is caused by absence or deficiency of …

Respiratory muscle weakness results in substantial discomfort, disability, and ultimately
death in many neuromuscular diseases. Respiratory system impairment manifests as …

BACKGROUND: Critically ill mechanically ventilated patients experience impaired airway
clearance due to ineffective cough and impaired secretion mobilization. Cough …