Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

Highlights•Convergence between axon regeneration ability and abnormal synaptic structure
and function.•Axon regeneration, neuronal circuit assembly and recovery of functions in the …

Introduction Spinal cord injury (SCI) affects 25,000–50,000 people around the world each
year and there is no cure for SCI patients currently. The primary injury damages spinal cord …

Significance: Nicotinamide adenine dinucleotide (NAD+) participates in redox reactions and
NAD+-dependent signaling processes, which involve the cleavage of NAD+ coupled to …

Highlights•DLK is an evolutionarily conserved sensor of axonal damage and cytoskeletal
stress.•DLK coordinates both regenerative and degenerative responses to axonal …

Axonal regrowth is crucial for recovery from CNS injury but is severely restricted in adult
mammals. We used a genome-wide loss-of-function screen for factors limiting axonal …

ADP-ribosylation is a reversible posttranslational modification used to regulate protein
function. ADP-ribosyltransferases transfer ADP-ribose from NAD+ to the target protein, and …

Atr is a serine/threonine kinase, known to sense single-stranded DNA breaks and activate
the DNA damage checkpoint by phosphorylating Chek1, which inhibits Cdc25, causing cell …

Neurons face a series of morphological and molecular changes following trauma and in the
progression of neurodegenerative disease. In neurons capable of mounting a spontaneous …

Caenorhabditis elegans (C. elegans) is gaining recognition and importance as an
organismic model for toxicity testing in line with the 3Rs principle (replace, reduce, refine). In …