Alcohol: a simple nutrient with complex actions on bone in the adult skeleton

GW Gaddini, RT Turner, KA Grant… - Alcoholism: clinical …, 2016 - Wiley Online Library
Background Alcohol is an important nonessential component of diet, but the overall impact
of drinking on bone health, especially at moderate levels, is not well understood. Bone …

Cellular and molecular mechanisms of alcohol-induced osteopenia

Z Luo, Y Liu, Y Liu, H Chen, S Shi, Y Liu - Cellular and Molecular Life …, 2017 - Springer
Alcoholic beverages are widely consumed, resulting in a staggering economic cost in
different social and cultural settings. Types of alcohol consumption vary from light occasional …

Actinobacillus actinomycetemcomitans Lipopolysaccharide‐Mediated Experimental Bone Loss Model for Aggressive Periodontitis

JE Rogers, F Li, DD Coatney, C Rossa Jr… - Journal of …, 2007 - Wiley Online Library
Background: Bacterial constituents, such as Gram‐negative derived lipopolysaccharide
(LPS), can initiate inflammatory bone loss through induction of host‐derived inflammatory …

Dietary‐induced serum phenolic acids promote bone growth via p38 MAPK/β‐catenin canonical Wnt signaling

JR Chen, OP Lazarenko, X Wu, J Kang… - Journal of Bone and …, 2010 - academic.oup.com
Diet and nutritional status are critical factors that influences bone development. In this report
we demonstrate that a mixture of phenolic acids found in the serum of young rats fed …

Estrogens and atherosclerosis: insights from animal models and cell systems

JR Nofer - Journal of molecular endocrinology, 2012 - jme.bioscientifica.com
Estrogens not only play a pivotal role in sexual development but are also involved in several
physiological processes in various tissues including vasculature. While several …

Low bone mineral density and impaired bone metabolism in young alcoholic patients without liver cirrhosis: a cross‐sectional study

P Malik, RW Gasser, G Kemmler… - Alcoholism: Clinical …, 2009 - Wiley Online Library
Background: Osteoporosis is regularly mentioned as a consequence of alcoholism.
Ethanol′ s direct effect on bone‐modeling cells as well as alcoholism‐related “life‐style …

Obesity reduces bone density associated with activation of PPARγ and suppression of Wnt/β-catenin in rapidly growing male rats

JR Chen, OP Lazarenko, X Wu, Y Tong, ML Blackburn… - PloS one, 2010 - journals.plos.org
Background It is well established that excessive consumption of a high fat diet (HFD) results
in obesity; however, the consequences of obesity on postnatal skeletal development have …

A role for ethanol‐induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/β‐catenin signaling

JR Chen, OP Lazarenko, K Shankar… - Journal of Bone and …, 2010 - academic.oup.com
The mechanisms by which chronic ethanol intake induces bone loss remain unclear. In
females, the skeletal response to ethanol varies depending on physiologic status (eg …

miR‐136‐3p targets PTEN to regulate vascularization and bone formation and ameliorates alcohol‐induced osteopenia

Y Chen, H Yu, D Zhu, P Liu, J Yin, D Liu… - The FASEB …, 2020 - Wiley Online Library
Alcohol consumption is regarded as one of the leading risk factors for secondary
osteopenia. Coupled angiogenesis and osteogenesis via distinct type‐H vessels …

Puerarin stimulates proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells via ER-dependent MEK/ERK and PI3K/Akt …

Y Wang, WL Wang, WL Xie, LZ Li, J Sun, WJ Sun… - Phytomedicine, 2013 - Elsevier
Puerarin, the main isoflavone glycoside found in the Chinese herb radix of Pueraria lobata
(Willd.) Ohwi, has received increasing attention because of its possible role in the prevention …