Fibroblast activation protein-α (FAP) is a type-II transmembrane serine protease expressed
almost exclusively to pathological conditions including fibrosis, arthritis, and cancer. Across …

One of the most exciting new therapies for cancer involves the use of autologous T cells that
are engineered to recognize and destroy cancerous cells. Patients with previously …

Purpose Fibroblast activation protein (FAP) is a membrane-bound protease that has limited
expression in normal adult tissues but is highly expressed in the tumor microenvironment of …

The majority of chimeric antigen receptor (CAR) T-cell research has focused on attacking
cancer cells. Here, we show that targeting the tumor-promoting, nontransformed stromal …

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly affects
synovial joints. During the course of RA, the synovium transforms into hyperplastic invasive …

Purpose The lack of effective molecular biomarkers to monitor idiopathic pulmonary fibrosis
(IPF) activity or treatment response remains an unmet clinical need. Herein, we determined …

Fibrosis is the formation of fibrous connective tissue in response to injury. It is characterized
by the accumulation of extracellular matrix components, particularly collagen, at the site of …

We performed a genome-wide association study of non-Hispanic, white individuals with
fibrotic idiopathic interstitial pneumonias (IIPs; n= 1,616) and controls (n= 4,683), with follow …

Activated fibroblasts are key players in the injury response, tumorigenesis, fibrosis, and
inflammation. Dichotomous outcomes in response to varied stroma-targeted therapies in …

Membrane-bound proteases have recently emerged as critical mediators of tumorigenesis,
angiogenesis, and metastasis. However, the mechanisms by which they regulate these …