The immunopathogenesis of rheumatoid arthritis (RA) spans decades, beginning with the
production of autoantibodies against post-translationally modified proteins (checkpoint 1) …

Well into the 21st century, we still triage acute myocardial infarction on the basis of the
presence or absence of ST-segment elevation, a century-old technology. Meanwhile, we …

Beginning with the sixth decade of life, the human immune system undergoes dramatic
aging-related changes, which continuously progress to a state of immunosenescence. The …

Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

Objective To compare the incidence of cardiovascular (CV) events in persons with
rheumatoid arthritis (RA) with that in people from the general population, adjusting for …

Evidence is emerging that the process of immune aging is a mechanism leading to
autoimmunity. Over lifetime, the immune system adapts to profound changes in …

Vascular disease is a progressive inflammatory condition fuelled by an unhealthy lifestyle of
physical inactivity, cholesterol-rich diet, and smoking. Together with endogenous factors …

The accumulation of CD28− T cells, particularly within the CD8 subset, is one of the most
prominent changes during T-cell homeostasis and function associated with aging in …

Experimental models of atherogenesis have provided a growing body of information about
molecular mechanisms of plaque growth; however, transition from coronary stability to …

Background Interleukin (IL)-18 is a potent proinflammatory cytokine with potential
atherogenic properties. Its expression and role in atherosclerosis, however, are unknown …