Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …

Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

The generation of organoids is one of the biggest scientific advances in regenerative
medicine. Here, by lengthening the time that human pluripotent stem cells (hPSCs) were …

Eukaryotic gene regulation is mediated by cis-regulatory elements, which are embedded
within the vast non-coding genomic space and recognized by the transcription factors in a …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Regulation of protein synthesis is a vital step in controlling gene expression, especially
during development. Over the last 10 years, it has become clear that rather than being …

Recent discoveries in stem cell and developmental biology have introduced a new era
marked by the generation of in vitro models that recapitulate early mammalian development …

We are living through an unprecedented accumulation of data on gene expression by
macrophages, reflecting their origin, distribution, and localization within all organs of the …

The first lineage choice in human embryo development separates trophectoderm from the
inner cell mass. Naïve human embryonic stem cells are derived from the inner cell mass and …

DNA: RNA hybrids play key roles in both physiological and disease states by regulating
chromatin and genome organization. Their homeostasis during cell differentiation and cell …