Clinical epigenetics: seizing opportunities for translation
M Berdasco, M Esteller - Nature Reviews Genetics, 2019 - nature.com
Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …
Translational control of stem cell function
JA Saba, K Liakath-Ali, R Green, FM Watt - Nature reviews Molecular …, 2021 - nature.com
Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …
cell types. Research has focused primarily on how these processes are regulated at a …
Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells
The generation of organoids is one of the biggest scientific advances in regenerative
medicine. Here, by lengthening the time that human pluripotent stem cells (hPSCs) were …
medicine. Here, by lengthening the time that human pluripotent stem cells (hPSCs) were …
Transposable elements as a potent source of diverse cis-regulatory sequences in mammalian genomes
V Sundaram, J Wysocka - Philosophical Transactions of …, 2020 - royalsocietypublishing.org
Eukaryotic gene regulation is mediated by cis-regulatory elements, which are embedded
within the vast non-coding genomic space and recognized by the transcription factors in a …
within the vast non-coding genomic space and recognized by the transcription factors in a …
New developments in the biology of fibroblast growth factors
DM Ornitz, N Itoh - WIREs mechanisms of disease, 2022 - Wiley Online Library
The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …
Ribosome heterogeneity and specialization in development
Regulation of protein synthesis is a vital step in controlling gene expression, especially
during development. Over the last 10 years, it has become clear that rather than being …
during development. Over the last 10 years, it has become clear that rather than being …
A new era of stem cell and developmental biology: from blastoids to synthetic embryos and beyond
Y Kim, I Kim, K Shin - Experimental & Molecular Medicine, 2023 - nature.com
Recent discoveries in stem cell and developmental biology have introduced a new era
marked by the generation of in vitro models that recapitulate early mammalian development …
marked by the generation of in vitro models that recapitulate early mammalian development …
The mononuclear phagocytic system. Generation of diversity
S Gordon, A Plüddemann - Frontiers in immunology, 2019 - frontiersin.org
We are living through an unprecedented accumulation of data on gene expression by
macrophages, reflecting their origin, distribution, and localization within all organs of the …
macrophages, reflecting their origin, distribution, and localization within all organs of the …
Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation
B Kumar, C Navarro, N Winblad, JP Schell, C Zhao… - Nature Cell …, 2022 - nature.com
The first lineage choice in human embryo development separates trophectoderm from the
inner cell mass. Naïve human embryonic stem cells are derived from the inner cell mass and …
inner cell mass. Naïve human embryonic stem cells are derived from the inner cell mass and …
Genome-wide R-loop landscapes during cell differentiation and reprogramming
DNA: RNA hybrids play key roles in both physiological and disease states by regulating
chromatin and genome organization. Their homeostasis during cell differentiation and cell …
chromatin and genome organization. Their homeostasis during cell differentiation and cell …