Toward computational neuroconstructivism: a framework for developmental systems neuroscience

DE Astle, MH Johnson, D Akarca - Trends in Cognitive Sciences, 2023 - cell.com
Brain development is underpinned by complex interactions between neural assemblies,
driving structural and functional change. This neuroconstructivism (the notion that neural …

Colloquium: Multiscale modeling of brain network organization

C Presigny, F De Vico Fallani - Reviews of Modern Physics, 2022 - APS
A complete understanding of the brain requires an integrated description of the numerous
scales and levels of neural organization. This means studying the interplay of genes and …

Modeling spatial, developmental, physiological, and topological constraints on human brain connectivity

S Oldham, BD Fulcher, K Aquino, A Arnatkevičiūtė… - Science …, 2022 - science.org
The complex connectivity of nervous systems is thought to have been shaped by competitive
selection pressures to minimize wiring costs and support adaptive function. Accordingly …

A shifting role of thalamocortical connectivity in the emergence of cortical functional organization

S Park, KV Haak, S Oldham, H Cho, K Byeon… - Nature …, 2024 - nature.com
The cortical patterning principle has been a long-standing question in neuroscience, yet
how this translates to macroscale functional specialization in the human brain remains …

A generative network model of neurodevelopmental diversity in structural brain organization

D Akarca, PE Vértes, ET Bullmore, DE Astle - Nature communications, 2021 - nature.com
The formation of large-scale brain networks, and their continual refinement, represent crucial
developmental processes that can drive individual differences in cognition and which are …

The adaptive stochasticity hypothesis: Modeling equifinality, multifinality, and adaptation to adversity

S Carozza, D Akarca, D Astle - Proceedings of the National …, 2023 - National Acad Sciences
Neural phenotypes are the result of probabilistic developmental processes. This means that
stochasticity is an intrinsic aspect of the brain as it self-organizes over a protracted period. In …

[HTML][HTML] Parameter estimation for connectome generative models: Accuracy, reliability, and a fast parameter fitting method

Y Liu, C Seguin, S Mansour, S Oldham, R Betzel… - Neuroimage, 2023 - Elsevier
Generative models of the human connectome enable in silico generation of brain networks
based on probabilistic wiring rules. These wiring rules are governed by a small number of …

Homophilic wiring principles underpin neuronal network topology in vitro

D Akarca, AWE Dunn, PJ Hornauer, S Ronchi… - BioRxiv, 2022 - biorxiv.org
Economic efficiency has been a popular explanation for how networks self-organize within
the developing nervous system. However, the precise nature of the economic negotiations …

Data-driven approaches to neuroimaging analysis to enhance psychiatric diagnosis and therapy

X Zhang, U Braun, H Tost, DS Bassett - Biological psychiatry: cognitive …, 2020 - Elsevier
Combining advanced neuroimaging with novel computational methods in network science
and machine learning has led to increasingly meaningful descriptions of structure and …

Network neuroscience and the connectomics revolution

RF Betzel - Connectomic deep brain stimulation, 2022 - Elsevier
Connectomics and network neuroscience offer quantitative scientific frameworks for
modeling and analyzing networks of structurally and functionally interacting neurons …