Alcohol use produces wide-ranging and diverse effects on the central nervous system. It
influences intracellular signaling mechanisms, leading to changes in gene expression …

Drug addiction and the circuitry for learning and memory are intimately intertwined. Drugs of
abuse create strong, inappropriate, and lasting memories that contribute to many of their …

Alternative splicing increases neuronal transcriptomic complexity throughout animal
phylogeny. To delve into the mechanisms controlling the assembly and evolution of this …

The brain constantly compares past and present experiences to predict the future, thereby
enabling instantaneous and future behavioral adjustments. Integration of external …

Alcohol use disorder (AUD) is a complex genetic disorder characterized by problems arising
from excessive alcohol consumption. Identifying functional genetic variations that contribute …

Understanding the nature of the molecular mechanisms underlying memory formation,
consolidation, and forgetting are some of the fascinating questions in modern neuroscience …

We previously discovered using transcriptomics that rats undergoing withdrawal after
chronic ethanol exposure had increased expression of several genes encoding RNA …

Repeated exposure to alcohol alters neuromolecular signaling that influences acute and
long-lasting behaviors underlying Alcohol Use Disorder (AUD). Recent animal model …

Background Gene regulation is critical for proper cellular function. Next-generation
sequencing technology has revealed the presence of regulatory networks that regulate gene …

The formation of long-term memories requires changes in the transcriptional program and
de novo protein synthesis. One of the critical regulators for long-term memory (LTM) …