Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells,
and cause tissue extravasation. Given these properties, their role in anti-tumor immune …

Checkpoint blockade therapy has been proven to be highly active across many cancer types
but emerging evidence indicates that the therapeutic benefit is limited to a subset of patients …

In tumor-bearing mice, cyclic fasting or fasting-mimicking diets (FMD) enhance the activity of
antineoplastic treatments by modulating systemic metabolism and boosting antitumor …

We investigated the role of chemokines in regulating T cell accumulation in solid tumors.
CCL5 and CXCL9 overexpression was associated with CD8+ T cell infiltration in solid …

Purpose: Response rates to immune checkpoint blockade (ICB; anti-PD-1/anti-CTLA-4)
correlate with the extent of tumor immune infiltrate, but the mechanisms underlying the …

Antibody targeting of the immune checkpoint receptor PD1 produces therapeutic activity in a
variety of solid tumors, but most patients exhibit partial or complete resistance to treatment …

T-cell trafficking at vascular sites has emerged as a key step in antitumour immunity.
Chemokines are credited with guiding the multistep recruitment of CD8+ T cells across …

Purpose: Nivolumab, an anti-PD-1 immune checkpoint inhibitor, improved overall survival
versus everolimus in a phase 3 trial of previously treated patients with metastatic renal cell …

Two-dimensional transition metal carbides/carbonitrides known as MXenes are rapidly
growing as multimodal nanoplatforms in biomedicine. Here, taking SARS-CoV-2 as a model …

Marching into the second decade after the approval of ipilimumab, it is clear that immune
checkpoint inhibitors (ICIs) have dramatically improved the prognosis of melanoma …