Ghrelin: structure and function
M Kojima, K Kangawa - Physiological reviews, 2005 - journals.physiology.org
Small synthetic molecules called growth hormone secretagogues (GHSs) stimulate the
release of growth hormone (GH) from the pituitary. They act through the GHS-R, a G protein …
release of growth hormone (GH) from the pituitary. They act through the GHS-R, a G protein …
Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin
Ghrelin is a peptide predominantly produced by the stomach. Ghrelin displays strong GH-
releasing activity. This activity is mediated by the activation of the so-called GH …
releasing activity. This activity is mediated by the activation of the so-called GH …
Ghrelin—a hormone with multiple functions
M Korbonits, AP Goldstone, M Gueorguiev… - Frontiers in …, 2004 - Elsevier
Ghrelin is brain-gut peptide with growth hormone-releasing and appetite-inducing activities.
It is mainly secreted from the stomach mucosa but it is also expressed widely in different …
It is mainly secreted from the stomach mucosa but it is also expressed widely in different …
Ghrelin gene products and the regulation of food intake and gut motility
CY Chen, A Asakawa, M Fujimiya, SD Lee… - Pharmacological reviews, 2009 - ASPET
A breakthrough using “reverse pharmacology” identified and characterized acyl ghrelin from
the stomach as the endogenous cognate ligand for the growth hormone (GH) secretagogue …
the stomach as the endogenous cognate ligand for the growth hormone (GH) secretagogue …
Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic β-cells and human islets: involvement of 3′, 5′-cyclic adenosine …
R Granata, F Settanni, L Biancone, L Trovato… - …, 2007 - academic.oup.com
Among its pleiotropic actions, ghrelin modulates insulin secretion and glucose metabolism.
Herein we investigated the role of ghrelin in pancreatic β-cell proliferation and apoptosis …
Herein we investigated the role of ghrelin in pancreatic β-cell proliferation and apoptosis …
[HTML][HTML] Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system
OBJECTIVE: To summarize the effects of novel hormones (leptin, ghrelin, adiponectin,
resistin, and PYY3-36) secreted from adipose tissue and the gastrointestinal tract that have …
resistin, and PYY3-36) secreted from adipose tissue and the gastrointestinal tract that have …
Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor
G Muccioli, N Pons, C Ghè, F Catapano… - European journal of …, 2004 - Elsevier
Besides possessing a strong growth hormone (GH)-releasing activity, the gastrointestinal
octanoylated peptide ghrelin has been reported to antagonize lipolysis in rat adipocytes. It is …
octanoylated peptide ghrelin has been reported to antagonize lipolysis in rat adipocytes. It is …
Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells
Ghrelin is a 28-amino-acid peptide identified in the stomach as an endogenous ligand of the
growth hormone secretagogue receptor (GHS-R) that strongly stimulates the release of …
growth hormone secretagogue receptor (GHS-R) that strongly stimulates the release of …
Ghrelin and des-acyl ghrelin promote differentiation and fusion of C2C12 skeletal muscle cells
N Filigheddu, VF Gnocchi, M Coscia… - Molecular biology of …, 2007 - Am Soc Cell Biol
Ghrelin is an acylated peptidyl gastric hormone acting on the pituitary and hypothalamus to
stimulate appetite, adiposity, and growth hormone release, through activation of growth …
stimulate appetite, adiposity, and growth hormone release, through activation of growth …
Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes
MJ Iglesias, R Piñeiro, M Blanco… - Cardiovascular …, 2004 - academic.oup.com
Objective: Ghrelin, the endogenous ligand of growth hormone secretagogue receptor (GHS-
R), acts on the pituitary and the hypothalamus to stimulate the release of growth hormone …
R), acts on the pituitary and the hypothalamus to stimulate the release of growth hormone …