Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide.
Although treatments have improved, development of novel therapies for patients with CVD …

Autophagy is a catabolic recycling pathway triggered by various intra-or extracellular stimuli
that is conserved from yeast to mammals. During autophagy, diverse cytosolic constituents …

Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have enormous potential
for the study of human cardiac disorders. However, their physiological immaturity severely …

Autophagy is a highly conserved degradation process by which intracellular components,
including soluble macromolecules (eg nucleic acids, proteins, carbohydrates, and lipids) …

The living cell is an ever changing, responsive, and adaptive environment where proteins
play key roles in all processes and functions. While the scientific community focused for a …

Neurodegenerative diseases, such as Alzheimer's disease Parkinson's disease,
Huntington's disease, and amyotrophic lateral sclerosis, share a common cellular and …

Cardiomyocyte hypertrophy has been associated with diminished mitochondrial metabolism.
Mitochondria are crucial organelles for the production of ATP, and their morphology and …

The anticancer therapy of doxorubicin (Dox) has been limited by its acute and chronic
cardiotoxicity. In addition to a causative role of oxidative stress, autophagy appears to play …

Although mitochondria play a multifunctional role in cancer progression and Ca2+ signaling
is remodeled in a wide variety of tumors, the underlying mechanisms that link mitochondrial …

Despite the significant decline in mortality, cardiovascular diseases are still the leading
cause of death worldwide. Among them, myocardial infarction (MI) seems to be the most …