Podocytopathies

JB Kopp, HJ Anders, K Susztak, MA Podestà… - Nature Reviews …, 2020 - nature.com
Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …

Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms

JE Hall, JM do Carmo, AA da Silva, Z Wang… - Circulation …, 2015 - Am Heart Assoc
Excess weight gain, especially when associated with increased visceral adiposity, is a major
cause of hypertension, accounting for 65% to 75% of the risk for human primary (essential) …

Obesity, kidney dysfunction, and inflammation: interactions in hypertension

JE Hall, AJ Mouton, AA da Silva… - Cardiovascular …, 2021 - academic.oup.com
Abstract Obesity contributes 65–75% of the risk for human primary (essential) hypertension
(HT) which is a major driver of cardiovascular and kidney diseases. Kidney dysfunction …

Obesity, hypertension, and chronic kidney disease

ME Hall, JM do Carmo, AA da Silva… - … journal of nephrology …, 2014 - Taylor & Francis
Obesity is a major risk factor for essential hypertension, diabetes, and other comorbid
conditions that contribute to development of chronic kidney disease. Obesity raises blood …

Hypertension and cardiomyopathy associated with chronic kidney disease: epidemiology, pathogenesis and treatment considerations

JP Law, L Pickup, D Pavlovic, JN Townend… - Journal of Human …, 2023 - nature.com
Chronic kidney disease (CKD) is a complex condition with a prevalence of 10–15%
worldwide. An inverse-graded relationship exists between cardiovascular events and …

Obesity and cardiovascular risk: a call for action from the European Society of Hypertension Working Group of Obesity, Diabetes and the High-risk Patient and …

V Kotsis, K Tsioufis, C Antza, G Seravalle… - Journal of …, 2018 - journals.lww.com
Obesity predisposes for atrial fibrillation, heart failure, sudden cardiac death, renal disease
and ischemic stroke, which are the main causes of cardiovascular hospitalization and …

Growth-dependent podocyte failure causes glomerulosclerosis

A Fukuda, MA Chowdhury… - Journal of the …, 2012 - journals.lww.com
Podocyte depletion leads to glomerulosclerosis, but whether an impaired capacity of
podocytes to respond to hypertrophic stress also causes glomerulosclerosis is unknown. We …

Visceral adipose accumulation increased the risk of hyperuricemia among middle-aged and elderly adults: a population-based study

X Huang, X Jiang, L Wang, L Chen, Y Wu… - Journal of Translational …, 2019 - Springer
Background The role of body fat distribution in uric acid metabolism is still ambiguity. We
aimed to investigate the independent contribution of visceral adipose measured by visceral …

High rates of central obesity and sarcopenia in CKD irrespective of renal replacement therapy–an observational cross-sectional study

J Dierkes, H Dahl, N Lervaag Welland, K Sandnes… - BMC nephrology, 2018 - Springer
Background Poor nutritional status of patients with renal disease has been associated with
worsening of renal function and poor health outcomes. Simply measuring weight and height …

Obesity: a perspective from hypertension

D Susic, J Varagic - Medical Clinics, 2017 - medical.theclinics.com
The prevalence of overweight and obesity in children and adults continues to increase
worldwide and, because of their association with cardiovascular disorders, diabetes, and …