Importance A previous meta-analysis of the association between alcohol use and all-cause
mortality found no statistically significant reductions in mortality risk at low levels of …

Purpose of Review A clear link between excessive alcohol consumption and cardiovascular
disease (CVD) has been established, but no consensus exists on the effects of moderate …

In Japan, a super-aged society, deaths from atherosclerotic cardiovascular disease
(ASCVD), especially cardiac diseases including coronary artery disease (CAD) such as …

Background Genetic variants that affect alcohol use in East Asian populations could help
assess the causal effects of alcohol consumption on cause-specific mortality. We aimed to …

Background Alcohol consumption is an important risk factor for hepatic neoplastic and non-
neoplastic diseases. Questions remain, however, about the relevance to disease risk of …

Aim To test the association of alcohol consumption with total and cause‐specific mortality
risk. Design Prospective observational multi‐centre population‐based study. Setting Sixteen …

Background Evidence suggests that people who abstain from alcohol have a higher
mortality rate than those who drink low to moderate amounts. However, little is known about …

Background: Although the age-adjusted incidence and mortality of cancer and
cardiovascular disease (CVD) have been decreasing steadily in Japan, both diseases …

Objectives This population-based study aimed to evaluate the association between bowel
habits from midlife and dementia. Study design This was a cohort study using certification …

Methods Nested case-control studies and cohort studies involving the general population
published prior to July 2019 were searched. In total, 28 publications (31 cohorts) with 4,899 …