We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

Depression is a mental illness that affects the normal lives of over 300 million people.
Unfortunately, about 30% to 40% of patients do not adequately respond to pharmacotherapy …

Widespread appreciation that neuroplasticity is an essential feature of the neural system
controlling breathing has emerged only in recent years. In this chapter, we focus on …

Inflammation undermines neuroplasticity, including serotonin-dependent phrenic long-term
facilitation (pLTF) following moderate acute intermittent hypoxia (mAIH: 3, 5-min episodes …

Cardiac surgery with median sternotomy causes iatrogenic damage to the function of the
diaphragm muscle that is both temporary and permanent. Myocardial infarction itself causes …

Moderate acute intermittent hypoxia (mAIH) elicits a form of spinal, respiratory motor
plasticity known as phrenic long-term facilitation (pLTF). In middle-aged male and geriatric …

Plasticity is a fundamental property of the neural system controlling breathing. One key
example of respiratory motor plasticity is phrenic long-term facilitation (pLTF), a persistent …

Moderate acute intermittent hypoxia (mAIH) elicits a form of phrenic motor plasticity known
as phrenic long-term facilitation (pLTF), which requires spinal 5-HT2 receptor activation …

Opioids depress breathing by inhibition of interconnected respiratory nuclei in the pons and
medulla. Mu opioid receptor (MOR) agonists directly hyperpolarize a population of neurons …

Rationale Acute intermittent hypoxia (AIH) shows promise for enhancing motor recovery in
chronic spinal cord injuries and neurodegenerative diseases. However, human trials of AIH …