Cannabinoids are a group of compounds that mediate their effects through cannabinoid
receptors. The discovery of Δ9-tetrahydrocannabinol (THC) as the major psychoactive …

Cannabinoids apparently act on inflammation through mechanisms different fromthose of
agents such as nonsteroidal anti‐inflammatory drugs (NSAIDs). As a class, the …

Research on the chemistry and pharmacology of cannabinoids and endocannabinoids has
reached enormous proportions, with approximately 15,000 articles on Cannabis sativa L …

CB2, the cannabinoid receptor expressed primarily on hematopoietic cells and activated
microglia, mediates the immunoregulatory functions of cannabinoids. The involvement of …

Abstract Ajulemic acid (AJA, CT‐3, IP‐751, JBT‐101, anabasum) is a first‐in‐class,
synthetic, orally active, cannabinoid‐derived drug that preferentially binds to the CB2 …

Medical cannabis has entered mainstream medicine and is here to stay. Propelled by public
advocacy, the media and mostly anecdote rather than sound scientific study, patients …

The inflammatory response is a complex physiologic process that requires the coordinate
induction of cytokines, chemokines, angiogenic factors, effector‐enzymes, and proteases …

Introduction 3. The cannabinoids: A brief history 3.1. Cannabinoids and the discovery of
cannabinoid receptors 3.2. Endocannabinoids 3.2. 1 Anandamide 3.2. 2 2-arachidonoyl …

We recently reported that cannabidiol (CBD) exhibited a generalized suppressive effect on T-
cell functional activities in splenocytes directly exposed to CBD in vitro or isolated from CBD …

Cannabis has been used in medicinal preparations for centuries to treat diseases such as
chronic pain, neuropathy, and epilepsy. Recent research has identified anti-inflammatory …