Global epidemiology and outcomes of acute kidney injury
Acute kidney injury (AKI) is a commonly encountered syndrome associated with various
aetiologies and pathophysiological processes leading to decreased kidney function. In …
aetiologies and pathophysiological processes leading to decreased kidney function. In …
Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup
Consensus definitions have been reached for both acute kidney injury (AKI) and chronic
kidney disease (CKD) and these definitions are now routinely used in research and clinical …
kidney disease (CKD) and these definitions are now routinely used in research and clinical …
[HTML][HTML] ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury
Y Wang, M Zhang, R Bi, Y Su, F Quan, Y Lin, C Yue… - Redox biology, 2022 - Elsevier
The term ferroptosis coined in 2012 causes acute kidney injury (AKI). However, its pathway
mechanism in AKI is poorly understood. In this study, we conducted an RNA-sequence …
mechanism in AKI is poorly understood. In this study, we conducted an RNA-sequence …
A single number for advocacy and communication—worldwide more than 850 million individuals have kidney diseases
* These authors contributed equally to this work. A joint project by the American Society of
Nephrology (ASN), European Renal Association–European Dialysis and Transplant …
Nephrology (ASN), European Renal Association–European Dialysis and Transplant …
Recommendations on acute kidney injury biomarkers from the acute disease quality initiative consensus conference: a consensus statement
M Ostermann, A Zarbock, S Goldstein… - JAMA network …, 2020 - jamanetwork.com
Importance In the last decade, new biomarkers for acute kidney injury (AKI) have been
identified and studied in clinical trials. Guidance is needed regarding how best to …
identified and studied in clinical trials. Guidance is needed regarding how best to …
Mitochondrial dysfunction in diabetic kidney disease
JM Forbes, DR Thorburn - Nature Reviews Nephrology, 2018 - nature.com
Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …
disease, which are major risk factors for cardiovascular disease and death. Despite this …
DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury
Patients with acute kidney injury (AKI) frequently require kidney transplantation and
supportive therapies, such as rehydration and dialysis. Here, we show that radiolabelled …
supportive therapies, such as rehydration and dialysis. Here, we show that radiolabelled …
De novo NAD+ synthesis enhances mitochondrial function and improves health
E Katsyuba, A Mottis, M Zietak, F De Franco… - Nature, 2018 - nature.com
Nicotinamide adenine dinucleotide (NAD+) is a co-substrate for several enzymes, including
the sirtuin family of NAD+-dependent protein deacylases. Beneficial effects of increased …
the sirtuin family of NAD+-dependent protein deacylases. Beneficial effects of increased …
De novo NAD+ biosynthetic impairment in acute kidney injury in humans
A Poyan Mehr, MT Tran, KM Ralto, DE Leaf… - Nature medicine, 2018 - nature.com
Nicotinamide adenine dinucleotide (NAD+) extends longevity in experimental organisms,
raising interest in its impact on human health. De novo NAD+ biosynthesis from tryptophan …
raising interest in its impact on human health. De novo NAD+ biosynthesis from tryptophan …
Perioperative acute kidney injury
SD Gumbert, F Kork, ML Jackson, N Vanga… - …, 2020 - pubs.asahq.org
Perioperative organ injury is among the leading causes of morbidity and mortality of surgical
patients. Among different types of perioperative organ injury, acute kidney injury occurs …
patients. Among different types of perioperative organ injury, acute kidney injury occurs …