Global epidemiology and outcomes of acute kidney injury

EAJ Hoste, JA Kellum, NM Selby, A Zarbock… - Nature Reviews …, 2018 - nature.com
Acute kidney injury (AKI) is a commonly encountered syndrome associated with various
aetiologies and pathophysiological processes leading to decreased kidney function. In …

Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup

LS Chawla, R Bellomo, A Bihorac… - Nature Reviews …, 2017 - nature.com
Consensus definitions have been reached for both acute kidney injury (AKI) and chronic
kidney disease (CKD) and these definitions are now routinely used in research and clinical …

[HTML][HTML] ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury

Y Wang, M Zhang, R Bi, Y Su, F Quan, Y Lin, C Yue… - Redox biology, 2022 - Elsevier
The term ferroptosis coined in 2012 causes acute kidney injury (AKI). However, its pathway
mechanism in AKI is poorly understood. In this study, we conducted an RNA-sequence …

A single number for advocacy and communication—worldwide more than 850 million individuals have kidney diseases

KJ Jager, C Kovesdy, R Langham… - Nephrology Dialysis …, 2019 - academic.oup.com
* These authors contributed equally to this work. A joint project by the American Society of
Nephrology (ASN), European Renal Association–European Dialysis and Transplant …

Recommendations on acute kidney injury biomarkers from the acute disease quality initiative consensus conference: a consensus statement

M Ostermann, A Zarbock, S Goldstein… - JAMA network …, 2020 - jamanetwork.com
Importance In the last decade, new biomarkers for acute kidney injury (AKI) have been
identified and studied in clinical trials. Guidance is needed regarding how best to …

Mitochondrial dysfunction in diabetic kidney disease

JM Forbes, DR Thorburn - Nature Reviews Nephrology, 2018 - nature.com
Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …

DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury

D Jiang, Z Ge, HJ Im, CG England, D Ni… - Nature biomedical …, 2018 - nature.com
Patients with acute kidney injury (AKI) frequently require kidney transplantation and
supportive therapies, such as rehydration and dialysis. Here, we show that radiolabelled …

De novo NAD+ synthesis enhances mitochondrial function and improves health

E Katsyuba, A Mottis, M Zietak, F De Franco… - Nature, 2018 - nature.com
Nicotinamide adenine dinucleotide (NAD+) is a co-substrate for several enzymes, including
the sirtuin family of NAD+-dependent protein deacylases. Beneficial effects of increased …

De novo NAD+ biosynthetic impairment in acute kidney injury in humans

A Poyan Mehr, MT Tran, KM Ralto, DE Leaf… - Nature medicine, 2018 - nature.com
Nicotinamide adenine dinucleotide (NAD+) extends longevity in experimental organisms,
raising interest in its impact on human health. De novo NAD+ biosynthesis from tryptophan …

Perioperative acute kidney injury

SD Gumbert, F Kork, ML Jackson, N Vanga… - …, 2020 - pubs.asahq.org
Perioperative organ injury is among the leading causes of morbidity and mortality of surgical
patients. Among different types of perioperative organ injury, acute kidney injury occurs …