Molecular mechanisms of antibody-mediated rejection and accommodation in organ transplantation

I Kenta, K Takaaki - Nephron, 2021 - karger.com
Antibody-mediated rejection (ABMR) in organ transplantation has been recognized as the
main cause of graft rejection. Binding of donor-specific HLA antibody (DSA) and A/B blood …

[HTML][HTML] Sensitization in transplantation: assessment of risk 2022 working group meeting report

AR Tambur, O Bestard, P Campbell, AS Chong… - American Journal of …, 2023 - Elsevier
Abstract The Sensitization in Transplantation: Assessment of Risk workgroup is a
collaborative effort of the American Society of Transplantation and the American Society of …

Protection of transplants against antibody-mediated injuries: from xenotransplantation to allogeneic transplantation, mechanisms and therapeutic insights

D Kervella, S Le Bas-Bernardet, S Bruneau… - Frontiers in …, 2022 - frontiersin.org
Long-term allograft survival in allotransplantation, especially in kidney and heart
transplantation, is mainly limited by the occurrence of antibody-mediated rejection due to …

Coordinated circulating T follicular helper and activated B cell responses underlie the onset of antibody-mediated rejection in kidney transplantation

K Louis, C Macedo, E Bailly, L Lau… - Journal of the …, 2020 - journals.lww.com
Background Although antibody-mediated rejection (ABMR) has been long recognized as a
leading cause of allograft failure after kidney transplantation, the cellular and molecular …

[HTML][HTML] T-bet+ CD27+ CD21–B cells poised for plasma cell differentiation during antibody-mediated rejection of kidney transplants

K Louis, E Bailly, C Macedo, L Lau, B Ramaswami… - JCI insight, 2021 - ncbi.nlm.nih.gov
Alloimmune responses driven by donor-specific antibodies (DSAs) can lead to antibody-
mediated rejection (ABMR) in organ transplantation. Yet, the cellular states underlying …

Iguratimod attenuates macrophage polarization and antibody-mediated rejection after renal transplant by regulating KLF4

Z Hang, J Wei, M Zheng, Z Gui, H Chen… - Frontiers in …, 2022 - frontiersin.org
Background: This study aimed to explore the effect and mechanism of iguratimod (IGT) on
M1 macrophage polarization and antibody-mediated rejection (ABMR) after renal transplant …

Targeting T follicular helper cells to control humoral allogeneic immunity

K Louis, C Macedo, D Metes - Transplantation, 2021 - journals.lww.com
Humoral allogeneic immunity driven by anti-HLA donor-specific antibodies and antibody-
mediated rejection (AMR) significantly impede prolonged survival of organ allografts after …

Seeking standardized definitions for HLA-incompatible kidney transplants: a systematic review

SS Jatana, H Zhao, LM Bow, E Cozzi, I Batal… - …, 2023 - journals.lww.com
Background. There is no standard definition for “HLA incompatible” transplants. For the first
time, we systematically assessed how HLA incompatibility was defined in contemporary …

Early antibody-mediated kidney transplant rejection associated with anti-vimentin antibodies: a case report

C Rampersad, J Shaw, IW Gibson, C Wiebe… - American Journal of …, 2020 - Elsevier
Improving precision in predicting alloreactivity is an important unmet need and may require
individualized consideration of non-HLA antibodies. We report a 21-year-old man with …

HLA class II antibody activation of endothelial cells induces M2 macrophage differentiation in peripheral blood

Y Guo, B Zheng, P Tian, J Zheng, Y Li, X Ding… - Clinical and …, 2023 - Springer
Background Donor-specific human leukocyte antigen (HLA) class II antibodies (HLA-II Abs)
combined with allogeneic endothelial cells (ECs) mediate high-risk rejection in kidney …