Sinonasal diseases, such as rhinosinusitis, affect up to 12% of individuals each year which
constitutes these diseases as some of the most common medical conditions in the world …

The cause of chronic rhinosinusitis (CRS) remains unclear. Study of the genetic
susceptibility to CRS might be a valuable strategy to understand the pathogenesis of this …

Group 2 innate lymphoid cells (ILC2s) have recently been identified in human nasal polyps,
but whether numbers of ILC2s differ by polyp endotype or are influenced by corticosteroid …

The upper airways play a critical role in the respiratory system by conditioning and clearing
contaminants from the inspired airstream before it accesses the lower respiratory system. 1 …

Olfactory sensory neurons (OSNs) are the receptor cells for the sense of smell. Although cell
bodies are located in the olfactory mucosa (OM) of the nasal cavity, OSN axons directly …

Rationale: Cystatin A and SPINK5 are endogenous protease inhibitors (EPIs) that may play
key roles in epithelial barrier function. Objectives: To investigate the roles of EPIs in the …

Background Rhinitis and rhinosinusitis are olfactory disorders caused by inflammation of the
nasal passage and paranasal sinuses. Although patients with chronic rhinosinusitis have …

Chronic rhinosinusitis (CRS) is a debilitating condition characterized by long-lasting
inflammation of the paranasal sinuses. It affects a significant portion of the population …

Chronic rhinosinusitis (CRS) is a chronic inflammatory condition affecting the nasal and
paranasal sinuses of approximately 11.5% of the United States adult population. Oral …

Objective Chronic sinusitis is a very common yet poorly understood medical condition with
significant morbidity. Hence, it remains an entity that is difficult to treat with unsatisfactory …