A review of anti-VEGF agents for proliferative diabetic retinopathy

P Osaadon, XJ Fagan, T Lifshitz, J Levy - Eye, 2014 - nature.com
Previous research has implicated vascular endothelial growth factor (VEGF) in the
pathogenesis of diabetic retinopathy (DR). Although many studies reviewed the use of anti …

Systemic and ocular safety of intravitreal anti-VEGF therapies for ocular neovascular disease

M Tolentino - Survey of ophthalmology, 2011 - Elsevier
The treatment of ocular neovascular diseases is being revolutionized by intravitreal
therapies targeting vascular endothelial growth factor (VEGF). Two agents are approved for …

Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema

MJ Elman, LP Aiello, RW Beck, NM Bressler… - Ophthalmology, 2010 - Elsevier
OBJECTIVE: Evaluate intravitreal 0.5 mg ranibizumab or 4 mg triamcinolone combined with
focal/grid laser compared with focal/grid laser alone for treatment of diabetic macular edema …

A review of clinical trials of anti-VEGF agents for diabetic retinopathy

BP Nicholson, AP Schachat - Graefe's Archive for Clinical and …, 2010 - Springer
Background Diabetic retinopathy (DR) is a leading cause of vision loss in the working-age
population worldwide. Many observational and preclinical studies have implicated vascular …

Anti-VEGF crunch syndrome in proliferative diabetic retinopathy: a review

Y Tan, A Fukutomi, MT Sun, S Durkin, J Gilhotra… - Survey of …, 2021 - Elsevier
Anti-vascular endothelial growth factor (anti-VEGF) crunch syndrome describes the
progression to tractional retinal detachment following intravitreal anti-VEGF therapy in an …

Pathophysiology and treatment of diabetic retinopathy

F Bandello, R Lattanzio, I Zucchiatti, C Del Turco - Acta diabetologica, 2013 - Springer
In the past years, the management of diabetic retinopathy (DR) relied primarily on a good
systemic control of diabetes mellitus, and as soon as the severity of the vascular lesions …

[HTML][HTML] Current management of diabetic tractional retinal detachments

MW Stewart, DJ Browning… - Indian Journal of …, 2018 - journals.lww.com
Twenty-five percent of diabetes-related vision loss stems from complications of proliferative
diabetic retinopathy (PDR). Panretinal photocoagulation has been the preferred treatment of …

[HTML][HTML] Targeting RGD-binding integrins as an integrative therapy for diabetic retinopathy and neovascular age-related macular degeneration

I Van Hove, TT Hu, K Beets, T Van Bergen… - Progress in retinal and …, 2021 - Elsevier
Integrins are a class of transmembrane receptors that are involved in a wide range of
biological functions. Dysregulation of integrins has been implicated in many pathological …

Anti‐VEGF therapy and the retina: an update

V Tah, HO Orlans, J Hyer, E Casswell… - Journal of …, 2015 - Wiley Online Library
Ocular angiogenesis and macular oedema are major causes of sight loss across the world.
Aberrant neovascularisation, which may arise secondary to numerous disease processes …

Intravitreal bevacizumab for prevention of early postvitrectomy hemorrhage in diabetic patients: a randomized clinical trial

H Ahmadieh, N Shoeibi, M Entezari, R Monshizadeh - Ophthalmology, 2009 - Elsevier
OBJECTIVE: To evaluate the effect of preoperative intravitreal bevacizumab (IVB) injection
on the rate of early (≤ 4weeks) postvitrectomy hemorrhage in patients with proliferative …