Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

Scanning ion conductance microscopy (SICM) has emerged as a versatile tool for studies of
interfaces in biology and materials science with notable utility in biophysical and …

Rhythmic increases in intracellular Ca2+ concentration underlie the contractile function of
the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and …

The canonical atrial myocyte (AM) is characterized by sparse transverse tubule (TT)
invaginations and slow intracellular Ca2+ propagation but exhibits rapid contractile …

Rationale: Disruption in subcellular targeting of Ca2+ signaling complexes secondary to
changes in cardiac myocyte structure may contribute to the pathophysiology of a variety of …

The calcium-activated protein phosphatase, calcineurin, lies at the intersection of protein
phosphorylation and calcium signaling cascades, where it provides an essential nodal point …

Aims Atrial fibrillation (AF) is associated with altered cAMP/PKA signaling and an AF-
promoting reduction of L-type Ca2+-current (ICa, L), the mechanisms of which are poorly …

Contraction of cardiomyocytes is dependent on sub-cellular structures called dyads, where
invaginations of the surface membrane (t-tubules) form functional junctions with the …

Aim In cardiomyocytes, transverse tubules (T-tubules) associate with the sarcoplasmic
reticulum (SR), forming junctional membrane complexes (JMCs) where L-type calcium …