Spinal cord injury (SCI) and spinal infarction lead to neurological complications and
eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major …

Neonatal hypoxic ischemic encephalopathy (HIE) presents a significant clinical burden with
its high mortality and morbidity rates globally. Therapeutic hypothermia (TH) is now standard …

Intrapartum-related events are the third leading cause of childhood mortality worldwide and
result in one million neurodisabled survivors each year. Infants exposed to a perinatal insult …

Iron deficiency, with or without anemia, is common in pregnant women. In fact, nearly 30% of
reproductive-age women are anemic worldwide, and anemia in pregnancy has an estimated …

Background Erythropoietin (EPO) and its receptor play a major role in embryonic brain, are
weakly expressed in normal postnatal/adult brain and up-regulated upon metabolic stress …

Preterm birth and infectious diseases are the most common causes of neonatal and early
childhood deaths worldwide. The rates of preterm birth have increased over recent decades …

Around 0.75 million babies worldwide suffer from moderate or severe hypoxic-ischemic
encephalopathy (HIE) each year resulting in around 400,000 babies with …

Hypoxic ischemic encephalopathy (HIE) is a serious birth complication affecting full-term
infants; 40% to 60% of affected infants die by 2 years old or have severe disabilities. Most …

Ischemic brain injury resulting from stroke arises from primary neuronal losses and by
inflammatory responses. Previous studies suggest that erythropoietin (EPO) attenuates both …

Glutamate excitotoxicity, oxidative stress, and acidosis are primary mediators of neuronal
death during ischemia and reperfusion. Astrocytes influence these processes in several …