The gut–brain axis refers to the bidirectional communication between the gut and the brain.
Four information carriers (vagal and spinal afferent neurons, immune mediators such as …

This review provides a summary of currently available pharmaceutical therapies for the
treatment of obesity, along with an overview of the pipeline of products currently in …

This textbook is the first to bring together and synthesize the neuropeptide research of the
past decade in such a comprehensive, scholarly manner. In recent years there has been …

Neuropeptide Y (NPY), one of the most abundant peptides in the nervous system, exerts its
effects via five receptor types, termed Y 1, Y 2, Y 4, Y 5 and Y 6. NPY's pleiotropic functions …

This review examines our current understanding of the roles of some of the best known
neuropeptides that have played major roles in our combined research programmes …

Glucose homeostasis is maintained by the glucoregulatory hormones, glucagon, insulin and
somatostatin, secreted from the islets of Langerhans. Glucagon is the body's most important …

Since hypothalamic obesity (HyOb) was first described over 120 years ago by Joseph
Babinski and Alfred Fröhlich, advances in molecular genetic laboratory techniques have …

Abstract NPY, PYY and PP constitute the so‐called NPY hormone family, which exert its
biological functions in humans through YRs (Y1, Y2, Y4 and Y5). Systematic modulation of …

Major indications for use of peptide-based therapeutics include endocrine functions
(especially diabetes mellitus and obesity), infectious diseases, and cancer. Whereas some …

BACKGROUND AND PURPOSE Peptide YY (PYY) and neuropeptide Y (NPY) are involved
in regulating gut and brain function. Because gastrointestinal inflammation is known to …