Progress in the mechanism and targeted drug therapy for COPD

C Wang, J Zhou, J Wang, S Li, A Fukunaga… - … and Targeted Therapy, 2020 - nature.com
Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …

The role of MIF on eosinophil biology and eosinophilic inflammation

MT Bozza, L Lintomen, JZ Kitoko, CN Paiva… - Clinical reviews in …, 2020 - Springer
Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine that participates in
innate and adaptive immune responses. MIF contributes to the resistance against infection …

Human macrophage migration inhibitory factor potentiates mesenchymal stromal cell efficacy in a clinically relevant model of allergic asthma

IJ Hawthorne, H Dunbar, C Tunstead, T Schorpp… - Molecular Therapy, 2023 - cell.com
Current asthma therapies focus on reducing symptoms but fail to restore existing structural
damage. Mesenchymal stromal cell (MSC) administration can ameliorate airway …

Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection

I Assunçao-Miranda, FA Amaral, FA Bozza… - The FASEB …, 2010 - Wiley Online Library
Dengue fever is an emerging viral disease transmitted by arthropods to humans in tropical
countries. Dengue hemorrhagic fever (DHF) is escalating in frequency and mortality rates …

[HTML][HTML] The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)

F Varyani, S Löser, KJ Filbey, Y Harcus, C Drurey… - Mucosal …, 2022 - Elsevier
Macrophage migration inhibitory factor (MIF) is a key innate immune mediator with
chemokine-and cytokine-like properties in the inflammatory pathway. While its actions on …

Advances and insights for small molecule inhibition of macrophage migration inhibitory factor

V Trivedi-Parmar, WL Jorgensen - Journal of medicinal chemistry, 2018 - ACS Publications
Macrophage migration inhibitory factor (MIF) is an upstream regulator of the immune
response whose dysregulation is tied to a broad spectrum of inflammatory and proliferative …

Blockade of MIF biological activity ameliorates house dust mite‐induced allergic airway inflammation in humanized MIF mice

H Dunbar, IJ Hawthorne, C Tunstead… - The FASEB …, 2023 - mural.maynoothuniversity.ie
Macrophage migration inhibitory factor (MIF) expression is controlled by a functional
promoter polymorphism, where the number of tetranucleotide repeats (CATTn) corresponds …

The role of MIF in chronic lung diseases: looking beyond inflammation

L Florez-Sampedro, A Soto-Gamez… - … of Physiology-Lung …, 2020 - journals.physiology.org
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been
associated with many diseases. Most studies found in literature describe MIF as a …

Macrophage migration inhibitory factor homologs of anisakis simplex suppress Th2 response in allergic airway inflammation model via CD4+ CD25+ Foxp3+ T cell …

SK Park, MK Cho, HK Park, KH Lee, SJ Lee… - The Journal of …, 2009 - journals.aai.org
We have cloned the macrophage migration inhibitory factor (MIF)-like protein (Anisakis
simplex (As)-MIF) from larvae of the whale worm (Anisakis simplex third-stage larvae) …

The MIF antagonist ISO-1 attenuates corticosteroid-insensitive inflammation and airways hyperresponsiveness in an ozone-induced model of COPD

KE Russell, KF Chung, CJ Clarke, AL Durham… - PLoS …, 2016 - journals.plos.org
Introduction Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine
associated with acute and chronic inflammatory disorders and corticosteroid insensitivity. Its …