Salivary gland function, development, and regeneration

AM Chibly, MH Aure, VN Patel… - Physiological …, 2022 - journals.physiology.org
Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …

[HTML][HTML] Radiation-induced salivary gland dysfunction: mechanisms, therapeutics and future directions

KJ Jasmer, KE Gilman, K Muñoz Forti… - Journal of clinical …, 2020 - mdpi.com
Salivary glands sustain collateral damage following radiotherapy (RT) to treat cancers of the
head and neck, leading to complications, including mucositis, xerostomia and …

Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and …

JAEM Zecha, JE Raber-Durlacher, RG Nair… - Supportive Care in …, 2016 - Springer
Purpose There is a large body of evidence supporting the efficacy of low-level laser therapy
(LLLT), more recently termed photobiomodulation (PBM) for the management of oral …

Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers

A Vissink, JB Mitchell, BJ Baum, KH Limesand… - International Journal of …, 2010 - Elsevier
The most significant long-term complication of radiotherapy in the head-and-neck region is
hyposalivation and its related complaints, particularily xerostomia. This review addresses …

Salivary gland hypofunction and xerostomia in head and neck radiation patients

SB Jensen, A Vissink, KH Limesand… - JNCI …, 2019 - academic.oup.com
Background The most manifest long-term consequences of radiation therapy in the head
and neck cancer patient are salivary gland hypofunction and a sensation of oral dryness …

[HTML][HTML] The salivary glands as a dose limiting organ of PSMA-targeted radionuclide therapy: a review of the lessons learnt so far

N Heynickx, K Herrmann, K Vermeulen… - Nuclear medicine and …, 2021 - Elsevier
At present, prostate cancer remains the second most occurring cancer in men, in Europe.
Treatment efficacy for therapy of advanced metastatic disease, and metastatic castration …

Salivary hypofunction: an update on aetiology, diagnosis and therapeutics

J Saleh, MAZ Figueiredo, K Cherubini, FG Salum - Archives of oral biology, 2015 - Elsevier
Saliva is of paramount importance for the maintenance of oral and general homeostasis.
Salivary hypofunction predispose patients to disorders such as dysgeusia, pain and burning …

Sensitivity of salivary glands to radiation: from animal models to therapies

O Grundmann, GC Mitchell… - Journal of dental …, 2009 - journals.sagepub.com
Radiation therapy for head and neck cancer causes significant secondary side-effects in
normal salivary glands, resulting in diminished quality of life for these individuals. Salivary …

[HTML][HTML] Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration

M Marinkovic, ON Tran, H Wang… - International Journal of …, 2023 - nature.com
Salivary gland (SG) dysfunction, due to radiotherapy, disease, or aging, is a clinical
manifestation that has the potential to cause severe oral and/or systemic diseases and …

Salivary glands regenerate after radiation injury through SOX2‐mediated secretory cell replacement

E Emmerson, AJ May, L Berthoin… - EMBO molecular …, 2018 - embopress.org
Salivary gland acinar cells are routinely destroyed during radiation treatment for head and
neck cancer that results in a lifetime of hyposalivation and co‐morbidities. A potential …