Cocaine, amphetamine, and methamphetamine abuse disorders are serious worldwide
health problems. To date, there are no FDA-approved medications for the treatment of these …

Background: The hypothalamic–pituitary–adrenal (HPA) axis dysregulation which was found
to have an important role in the pathophysiology of depression, suicide, and substance …

Methamphetamine (METH) has been a worldwide health threat for years. Recent studies
have reported that circular RNA (circRNA) are highly abundant and dynamically expressed …

Background and aims Methamphetamine (MA) is a psychostimulant associated with a high
relapse rate among patients with MA use disorder (MUD). Long-term use of MA is …

Rationale Drug and natural rewarding stimuli activate the mesolimbic dopaminergic system.
Both methamphetamine (Meth) and copulation to satiety importantly increase dopamine …

Methamphetamine abuse imposes a significant burden on individuals and society
worldwide, and an effective therapy of methamphetamine addiction would provide …

Conditioned place preference (CPP) paradigm in zebrafish has been used to measure drug
reward, but there is limited research on CPP reinstatement to determine relapse …

The orexinergic system is found to cooperate in mediating stress-induced drug relapse. The
orexinergic terminals innervate neurons of the hippocampal dentate gyrus (DG) which is a …

Repeated administration of methylamphetamine (MA) induces MA addiction, which is
featured by awfully unpleasant physical and emotional experiences after drug use is …

Recreational and medical use of stimulants among young adults have gained popularity in
the United States over the last decade and their use may increase vulnerability to brain …