Locus coeruleus: a new look at the blue spot

GR Poe, S Foote, O Eschenko, JP Johansen… - Nature Reviews …, 2020 - nature.com
The locus coeruleus (LC), or 'blue spot', is a small nucleus located deep in the brainstem
that provides the far-reaching noradrenergic neurotransmitter system of the brain. This …

Questions and controversies in the study of time-varying functional connectivity in resting fMRI

DJ Lurie, D Kessler, DS Bassett, RF Betzel… - Network …, 2020 - direct.mit.edu
The brain is a complex, multiscale dynamical system composed of many interacting regions.
Knowledge of the spatiotemporal organization of these interactions is critical for establishing …

A contextual binding theory of episodic memory: systems consolidation reconsidered

AP Yonelinas, C Ranganath, AD Ekstrom… - Nature Reviews …, 2019 - nature.com
Episodic memory reflects the ability to recollect the temporal and spatial context of past
experiences. Episodic memories depend on the hippocampus but have been proposed to …

The power of negative and positive episodic memories

SE Williams, JH Ford, EA Kensinger - Cognitive, Affective, & Behavioral …, 2022 - Springer
The power of episodic memories is that they bring a past moment into the present, providing
opportunities for us to recall details of the experiences, reframe or update the memory, and …

[HTML][HTML] Uncertainty and stress: Why it causes diseases and how it is mastered by the brain

A Peters, BS McEwen, K Friston - Progress in neurobiology, 2017 - Elsevier
The term 'stress'–coined in 1936–has many definitions, but until now has lacked a
theoretical foundation. Here we present an information-theoretic approach–based on the …

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

MJ Betts, E Kirilina, MCG Otaduy, D Ivanov… - Brain, 2019 - academic.oup.com
Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

The locus coeruleus-norepinephrine system in stress and arousal: unraveling historical, current, and future perspectives

JA Ross, EJ Van Bockstaele - Frontiers in psychiatry, 2021 - frontiersin.org
Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction,
and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and …

[HTML][HTML] Novelty and dopaminergic modulation of memory persistence: a tale of two systems

AJ Duszkiewicz, CG McNamara, T Takeuchi… - Trends in …, 2019 - cell.com
Adaptation to the ever-changing world is critical for survival, and our brains are particularly
tuned to remember events that differ from previous experiences. Novel experiences induce …

[HTML][HTML] Rapid reconfiguration of the functional connectome after chemogenetic locus coeruleus activation

V Zerbi, A Floriou-Servou, M Markicevic, Y Vermeiren… - Neuron, 2019 - cell.com
The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates
many fundamental brain functions. Studies in humans have suggested that strong LC …

The locus coeruleus: essential for maintaining cognitive function and the aging brain

M Mather, CW Harley - Trends in cognitive sciences, 2016 - cell.com
Research on cognitive aging has focused on how decline in various cortical and
hippocampal regions influence cognition. However, brainstem regions play essential …